Hydroxypropyl cellulose functionalized magnetite graphene oxide nanobiocomposite for chemo/photothermal therapy
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this work, graphene oxide nanosheets (GO) are dual functionalized with Fe3O4 nanoparticles and hydrox-ypropyl cellulose (CLS) for chemo/phototherapy. The TEM, XRD, FTIR, Raman, UV, TG, DLS, and VSM analyses were used to confirm the CLS and Fe3O4 incorporated GO (CLS@mGO) nanobiocomposite structure. Function-alization of magnetite graphene oxide surface by CLS not only improved biocompatibility, colloidal stability, and entrapment efficiency for paclitaxel (PTX) but also accelerated PTX release. Under 808 nm laser light, the CLS@mGO-PTX nanobiocomposite displayed good photothermal features. The CLS@mGO-PTX nano-biocomposite exhibited high photothermal conversion efficiency (47.85%) and photo stability. The notable synergistic chemo/photothermal impacts have also been determined by the in vitro experiments in killing MCF-7 cancer cells. The results of these experiments exhibited that compared to single phototherapy and chemotherapy, chemo/phototherapy could more effectively kill cancer cells by synergetic anticancer impact. Therefore, the CLS@mGO-PTX nanobiocomposite has great potential for chemo/phototherapy.
Açıklama
Anahtar Kelimeler
Magnetite graphene oxide; Hydroxypropyl cellulose; Iron oxide; Drug delivery; Chemo; photothermal therapy
Kaynak
Colloids and Surfaces A-Physicochemical and Engineering Aspects
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
656
