Hydroxypropyl cellulose functionalized magnetite graphene oxide nanobiocomposite for chemo/photothermal therapy

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dc.contributor.authorIsiklan, Nuran
dc.contributor.authorHussien, Nizamudin Awel
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2025-01-21T16:41:39Z
dc.date.available2025-01-21T16:41:39Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this work, graphene oxide nanosheets (GO) are dual functionalized with Fe3O4 nanoparticles and hydrox-ypropyl cellulose (CLS) for chemo/phototherapy. The TEM, XRD, FTIR, Raman, UV, TG, DLS, and VSM analyses were used to confirm the CLS and Fe3O4 incorporated GO (CLS@mGO) nanobiocomposite structure. Function-alization of magnetite graphene oxide surface by CLS not only improved biocompatibility, colloidal stability, and entrapment efficiency for paclitaxel (PTX) but also accelerated PTX release. Under 808 nm laser light, the CLS@mGO-PTX nanobiocomposite displayed good photothermal features. The CLS@mGO-PTX nano-biocomposite exhibited high photothermal conversion efficiency (47.85%) and photo stability. The notable synergistic chemo/photothermal impacts have also been determined by the in vitro experiments in killing MCF-7 cancer cells. The results of these experiments exhibited that compared to single phototherapy and chemotherapy, chemo/phototherapy could more effectively kill cancer cells by synergetic anticancer impact. Therefore, the CLS@mGO-PTX nanobiocomposite has great potential for chemo/phototherapy.
dc.description.sponsorshipScientific Research Projects Coordi-nation Unit of Kirikkale University; [2017/055, 2017]
dc.description.sponsorshipAcknowledgments The authors are thankful to the Scientific Research Projects Coordination Unit of Kirikkale University [Project number: 2017/055, 2017] for their financial support
dc.identifier.doi10.1016/j.colsurfa.2022.130322
dc.identifier.issn0927-7757
dc.identifier.issn1873-4359
dc.identifier.scopus2-s2.0-85140141407
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2022.130322
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24905
dc.identifier.volume656
dc.identifier.wosWOS:000875461000002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces A-Physicochemical and Engineering Aspects
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectMagnetite graphene oxide; Hydroxypropyl cellulose; Iron oxide; Drug delivery; Chemo; photothermal therapy
dc.titleHydroxypropyl cellulose functionalized magnetite graphene oxide nanobiocomposite for chemo/photothermal therapy
dc.typeArticle

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