Trpv2 Polymorphisms Change The Risk Of Type 2 Diabetes - Hashimoto Thyroiditis Comorbidity

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dc.contributor.authorArikan, F. Bulut
dc.contributor.authorOzdemir, F. A.
dc.contributor.authorSen, D.
dc.contributor.authorErdem, S.
dc.contributor.authorYorubulut, S.
dc.contributor.authorDogan, H.
dc.contributor.authorKeskin, L.
dc.date.accessioned2021-01-14T18:11:00Z
dc.date.available2021-01-14T18:11:00Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractContext. Thyroid disorders are common in diabetics and related to severe diabetic complications. TRPV2 ion channels have crucial functions in insulin secretion and glucose metabolism which have an important role in the pathophysiology of diabetes. Also, they have a significant effect on various immunological events that are involved in the HT pathophysiology. Objective. This study aimed to investigate rs14039 and rs4792742 polymorphisms of the TRPV2 ion channels in type 2 diabetes mellitus (T2DM, n=100) Hashimoto thyroiditis (HT, n=70) and comorbid T2DM and HT (T2DM+HT, n=100) patients and control (n=100). Design. Case-control study Subject and Methods. RT-PCR genotyping was used to determine rs14039 and rs4792742 polymorphisms with DNA samples of subjects and appropriate primer and probes. Besides, required biochemical analyses were performed. Results. It was determined that the frequencies of the rs14039 GG homozygote polymorphic genotype and the G allele were significantly higher in T2DM+HT patients compared to the control (p=0.03 and p=0.01, respectively) and that especially the GG genotype increases the risk of T2DM+HT 3.046-fold (p=0.01, OR=3.046). It was detected that the GG genotype increased the risk of HT 2.54-fold (p=0.05, OR=2.541). TRPV2 rs4792742 polymorphisms reduce the risk of HT and T2DM+HT comorbidity almost by half and have a protective effect against HT and T2DM+HT. Conclusion. The rs14039 GG genotype of the TRPV2 gene significantly increases the risks of development of T2DM+HT and HT disorders, may have a significant role in the pathophysiology of these diseases, also leading to predisposition for their development. Conversely, rs4792742 polymorphic genotypes have a strong protective effect against the HT and T2DM+HT comorbidity.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination UnitKirikkale University [2013/056]en_US
dc.description.sponsorshipThis study was supported by the Kirikkale University Scientific Research Projects Coordination Unit as a part of project No: 2013/056.en_US
dc.identifier.doi10.4183/aeb.2020.15
dc.identifier.endpage21en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85089621892
dc.identifier.scopusqualityQ4
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2020.15
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12851
dc.identifier.volume16en_US
dc.identifier.wosWOS:000557583600003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEDITURA ACAD ROMANEen_US
dc.relation.ispartofACTA ENDOCRINOLOGICA-BUCHAREST
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTRPV2en_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.subjectHashimoto Thyroiditisen_US
dc.subjectPolymorphismsen_US
dc.titleTrpv2 Polymorphisms Change The Risk Of Type 2 Diabetes - Hashimoto Thyroiditis Comorbidityen_US
dc.typeArticle

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