Effects of edaravone on testicular torsion-detorsion injury in rats

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dc.authorideroglu, oguz/0000-0001-7033-8566
dc.authoridSahin, Yasar/0000-0001-5936-4210
dc.authoridOZKABADAYI, YASIN/0000-0003-0326-3407
dc.authoridYildirim, Ebru/0000-0002-6289-0729
dc.authoridBILGE, Ahmet Bilgehan/0009-0007-8445-311X
dc.authoridUstuner, Evren/0000-0003-0932-1508
dc.contributor.authorSahin, Yasar
dc.contributor.authorUstuner, Evren
dc.contributor.authorTutun, Hidayet
dc.contributor.authorYildirim, Ebru
dc.contributor.authorEroglu, Oguz
dc.contributor.authorKurtdede, Efe
dc.contributor.authorOzkabadayi, Yasin
dc.date.accessioned2025-01-21T16:38:16Z
dc.date.available2025-01-21T16:38:16Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and objective: This study aimed to assess the protective ability of edaravone on testicular torsion-detorsion injury in rats. Methods: Eighteen adult male Sprague-Dawley rats were randomly divided into three groups: Sham group (control, n = 6); testicular torsion/detorsion (T/D group, n = 6) and T/D+edaravone (T/D+E group, n = 6). The spermatic cords of rats of the T/D group and the T/D+E group were rotated 720(degrees) in a clockwise direction and maintained for 120 min in this torsion position. Around 90 min after the torsion, edaravone at a dose of 10 mg/kg dissolved in saline was administered IP to the T/D+E group. The testicle was counter-rotated to its normal position to allow reperfusion for 4 h. Left testes of each animal were excised 240 min after beginning of reperfusion. Oxidative stress markers (TAS, TOS, SOD, and MDA) and apoptotic pathways (Caspase 3, Caspase 8, Caspase 9, Bcl-2, and Bax,) were assessed by ELISA methods. Also, testicles were subjected to the histopathologic and ultrasound examinations. Results: Ultrasound imaging showed that edaravone reduced the surface area and increased vascularization in testicles with T/D (p < 0.0001, p < 0.05, respectively). Edaravone pretreatment markedly decreased the levels of MDA, TOS, Bcl-2, Bax, Caspase 3, Caspase 8, and Caspase 9 (p < 0.0001). Also, it increased significantly TAS levels (p < 0.0001) and reduced insignificantly SOD activity. Histopathologic examinations demonstrated that edaravone significantly attenuated the histological damage caused by T/D in testicles. Conclusion: Taken together, the findings indicate that pretreatment of edaravone has protective effect against testicular T/D injury.
dc.identifier.doi10.1111/andr.13628
dc.identifier.endpage1927
dc.identifier.issn2047-2919
dc.identifier.issn2047-2927
dc.identifier.issue8
dc.identifier.pmid38482942
dc.identifier.scopus2-s2.0-85188255394
dc.identifier.scopusqualityQ1
dc.identifier.startpage1918
dc.identifier.urihttps://doi.org/10.1111/andr.13628
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24621
dc.identifier.volume12
dc.identifier.wosWOS:001184908000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcSMI; edaravone; ischemia/reperfusion; testicular torsion; testis; torsion-detorsion
dc.titleEffects of edaravone on testicular torsion-detorsion injury in rats
dc.typeArticle

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