Could maternal serum MFG-E8 level predict adverse first trimester pregnancy outcome? A preliminary study

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dc.contributor.authorElçi, Bircan
dc.contributor.authorYalçinkaya, Zeynep
dc.contributor.authorTekin, Ercan
dc.contributor.authorBakirci, Şükrü
dc.contributor.authorDayangan Sayan, Cemile
dc.contributor.authorKisa, Üçler
dc.contributor.authorKurdoğlu, Mertihan
dc.date.accessioned2025-01-21T16:27:12Z
dc.date.available2025-01-21T16:27:12Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: Milk fat globule-epidermal growth factor 8 (MFG-E8) is expressed in the endometrial epithelium and its expression increases during the implantation process. Due to this knowledge, we aimed to investigate the maternal serum MFG-E8 levels on both healthy pregnant women in the first trimester and pregnant women complicated with missed abortion and threatened abortion in the first trimester. Materials and methods: This prospective, cross-sectional study was conducted in a tertiary referral hospital, department of obstetrics between July 2020 and February 2021 after ethical committee approval. The study population was consisted of 30 healthy pregnant women (HP) in the first trimester, 30 pregnant women suffering from threatened abortion (TA) in the first trimester and 30 pregnant women suffering from missed abortion (MA) in the first trimester. Maternal serum MFG-E8 levels were analyzed with enzyme linked immunosorbent assay. Delivery and neonatal outcomes of the study population was evaluated. The continuous variables were compared among three groups with variance analysis with post hoc tests. The categorical variables were compared with chi-square and Fisher’s exact tests where applicable. Results: The mean age of the study population was 29.36 ± 5.31 years. There was no significant difference among three groups for parameters of age, body mass index, parity number, and gestational week. Despite being within normal ranges, the mean neutrophil and international normalized ratio values of the three groups showed statistically significant difference (p < 0.05). The mean maternal serum MFG-E8 levels of MA, TA, and HP groups were 270 ± 152.3, 414.7 ± 236.7, and 474 ± 222.5 ng/mL, respectively (p = 0.001). It was found that mean of MFG-E8 of the MA group was statistically significantly lower than those of the other two groups (p < 0.05). Conclusion: Although maternal serum MFG-E8 level seems to be a parameter that differ between live and nonlive pregnancies, studies with large number of cases are needed to discuss our results and to determine a cut-off value for prediction. © TÜBİTAK.
dc.description.sponsorshipKırıkkale University Scientific Research Foundation, (2020/83)
dc.identifier.doi10.55730/1300-0144.5614
dc.identifier.endpage543
dc.identifier.issn1300-0144
dc.identifier.issue2
dc.identifier.pmid37476868
dc.identifier.scopus2-s2.0-85159161586
dc.identifier.scopusqualityQ1
dc.identifier.startpage536
dc.identifier.trdizinid1180205
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5614
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1180205
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23292
dc.identifier.volume53
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectlive fetus; MFG-E8; missed abortion; pregnancy outcome
dc.titleCould maternal serum MFG-E8 level predict adverse first trimester pregnancy outcome? A preliminary study
dc.typeArticle

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