Investigation of the frequency of the mutant CCR5-?32 allele related to HIV resistance in Turkey

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dc.contributor.authorKarakaya, Gamze
dc.contributor.authorYıldıran, Fatma Azize Budak
dc.contributor.authorÇakır, Şükran Arıca
dc.date.accessioned2021-01-14T18:16:15Z
dc.date.available2021-01-14T18:16:15Z
dc.date.issued2013
dc.description.abstractAim: To determine the frequency with which the CCR5-Δ32 mutant allele caused resistance to HIV, which is main agent of AIDS in all geographic regions of Turkey. Materials and methods: Randomly selected human blood samples from 400 healthy individuals were collected. The polymerase chain reaction method was used to determine the CCR5-Δ32 polymorphism and samples were screened using 2 primers. Results: The frequency of wild alleles was found to be 0.9738 and the frequency of mutant alleles was found to be 0.0262. The highest frequency of the CCR5-Δ32 allele was found to be 0.0726 in the Central Anatolia region. The lowest frequency of the CCR5-Δ32 allele was found to be 0.0093 in the Southeast Anatolia and the Mediterranean regions. The mutant allele was not observed in any individuals from the Marmara region. Homozygosity was not observed in terms of this mutant allele in the individuals studied. Conclusion: According to the data obtained from this study, the frequency of CCR5-Δ32, except for in the Marmara region, showed parallelism with a decrease consistent with a north-south direction across the world. This study was conducted to determine the frequency of the CCR5-Δ32 allele, which is important for the evaluation of samples that are representative of all the geographic regions of Turkeyen_US
dc.identifier.citationKarakaya G., Yıldıran F. A. B., Çakır Ş. A. (2013). Investigation of the frequency of the mutant CCR5-Δ32 allele related to HIV resistance in Turkey. Turkish Journal of Medical Sciences, 43(6), 886 - 890.en_US
dc.identifier.endpage890en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84884942287
dc.identifier.scopusqualityQ1
dc.identifier.startpage886en_US
dc.identifier.trdizinid211718
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpFeE56RTRPQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12587/13058
dc.identifier.volume43en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleInvestigation of the frequency of the mutant CCR5-?32 allele related to HIV resistance in Turkeyen_US
dc.typeArticle

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