Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes

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dc.contributor.authorÖzer, Murat Atabey
dc.contributor.authorPolat, Nihat
dc.contributor.authorÖzen, Serkan
dc.contributor.authorOğurel, Tevfik
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.date.accessioned2020-06-25T18:22:58Z
dc.date.available2020-06-25T18:22:58Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.descriptionParlakpinar, Hakan/0000-0001-9497-3468; OZER, MURAT ATABEY/0000-0003-1807-6911
dc.description.abstractThe aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards. At the end of the work, the rabbits were sacrificed under high-dose anesthesia and then eye tissues were taken for histopathological analyses. In the PVR + APO group, histopathologic and ophthalmoscopic examination revealed significant decrease in PVR formation. As the result, it has been observed that APO at least partially inhibits PVR formation.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s10792-016-0318-0
dc.identifier.endpage605en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue3en_US
dc.identifier.pmid27495951
dc.identifier.scopus2-s2.0-84982976361
dc.identifier.scopusqualityQ2
dc.identifier.startpage599en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-016-0318-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6969
dc.identifier.volume37en_US
dc.identifier.wosWOS:000401918500022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApocyninen_US
dc.subjectEyeen_US
dc.subjectRabbiten_US
dc.subjectProliferative vitreoretinopathyen_US
dc.titleHistopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyesen_US
dc.typeArticle

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