Effects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms: A Prospective, Multicenter Study

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dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.authoridseyed resuli, ali/0000-0002-4262-1302
dc.authoridCETINER, HASAN/0000-0002-7218-6217
dc.authoridAydenizoz, Dogukan/0000-0003-4012-3841
dc.authoridTORUN, MUMTAZ TANER/0000-0002-5194-4234
dc.authoridAkbay, Makbule Ozlem/0000-0002-2459-8022
dc.contributor.authorCingi, Cemal
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorCukurova, Ibrahim
dc.contributor.authorDundar, Riza
dc.contributor.authorOsma, Ustun
dc.contributor.authorBal, Cengiz
dc.contributor.authorZirek, Alaattin
dc.date.accessioned2025-01-21T16:38:14Z
dc.date.available2025-01-21T16:38:14Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: This study aimed to evaluate how Rhinapi nasal spray affects symptoms of allergic rhinitis. Methods: In this prospective, multicenter, observational study, 10,000 patients (comprising 5028 males and 4972 females) exhibiting symptoms of allergic rhinitis (namely, nasal discharge, sneezing, nasal itching, and nasal obstruction) from different centers in different regions of Turkey were enrolled in the study between March 2022 and March 2023. All the patients wanted to participate in the study and were administered Rhinapi one puff to each nostril three times a day, for a period of 3 weeks. Total symptom scores, quality of life (QoL) scores, and otolaryngological examination scores were evaluated before and 3 weeks after treatment. Results: The scores for discharge from the nose, sneezing, nasal pruritus, and blockage of the nose all indicated improvement when compared to pre-medication and post-medication. This difference achieved statistical significance (P < .001). The mean total symptom score fell following treatment (P < .001): whilst the score was 11.09 +/- 3.41 before administering Rhinapi; after administration, the average score was 6.23 +/- 2.41. The mean QoL scores also altered after medication (P < .001), improving from a mean value of 6.44 +/- 1.55 to a mean of 7.31 +/- 1.24. Significant improvement was also noted in the scores for conchal color and degree of edema after the treatment had been administered (P < .001). Conclusion: The study demonstrates that Rhinapi nasal spray decreases total symptom scores, and results in improved QoL and otolaryngological examination scores. Propolis spray may be recommended for patients with allergic rhinitis alongside other treatments.
dc.description.sponsorshipBeeYou
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was sponsored by Bee&You. However, Bee&You did not solicit this research project or protocols with the investigators or the institution. Bee&You was not responsible for the management of the study, data processing, and reporting.
dc.identifier.doi10.1177/01455613231204209
dc.identifier.endpageNP198
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue4
dc.identifier.pmid38284348
dc.identifier.scopus2-s2.0-85183926713
dc.identifier.scopusqualityQ2
dc.identifier.startpageNP190
dc.identifier.urihttps://doi.org/10.1177/01455613231204209
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24605
dc.identifier.volume103
dc.identifier.wosWOS:001153229500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectpropolis; allergic rhinitis; nasal; total symptom score
dc.titleEffects of Anatolian Propolis and Hypertonic Saline Combination Nasal Spray on Allergic Rhinitis Symptoms: A Prospective, Multicenter Study
dc.typeArticle

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