The immunohistochemical approach to determine the origin and possible function of the juxtaoral organ in dogs

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dc.contributor.authorBahçelioğlu, M.
dc.contributor.authorÇalgüner, E.
dc.contributor.authorErdoğan, D.
dc.contributor.authorElmas, C.
dc.contributor.authorGozil, R.
dc.contributor.authorKeşkil, S.
dc.contributor.authorKadıoğlu, D.
dc.date.accessioned2020-06-25T17:40:25Z
dc.date.available2020-06-25T17:40:25Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.descriptionERDOGAN, DILEK/0000-0002-9981-9475; bahcelioglu, meltem/0000-0001-5279-3450; ERDOGAN, DILEK/0000-0002-1930-3584
dc.description.abstractObjective: In this study, we applied immunohistochemical techniques on the functionally little known organ of Chievitz (juxtaoral organ [JOO]) in dogs to determine its origin and possible function. Methods: The term abortive materials of 6 Doberman dogs were used for experimental procedures in July 2002 to June 2003 at Gazi University Faculty of Medicine, Ankara, Turkey, after routine light microscopic tissue preparation, the sections were stained with Masson's trichrome stain. In order to elucidate the function -related origin of the organ, we used epidermal growth factor (EGF-r), transforming growth factor (TGF-alpha) and nerve growth factor (NGF-beta) immunohistochemical stains. Results: We observed a very strong and 'widespread immunoreactivity of EGF-r and TGF-a on simple squamous capsular cells. We detected nerve growth factor-beta positivity in granular form both in simple squamous capsular cells and in neighboring connective tissue. However, we did not detect EGF-r reactivity on parenchymal cells except a weak immunoreactivity on central ones. We noticed transforming growth factor-a in most of the parenchymal cells while we observed NGF-beta strongly in all the parenchymal cells. Conclusion: These results may point out that the JOO may be of mesothelial or epithelial origin. Having NGF-alpha. positive granules and close relationship with blood vessels may imply a neurosecretory function. We believe that our study may add new perspectives to the function of the JOO.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage1534en_US
dc.identifier.issn0379-5284
dc.identifier.issue10en_US
dc.identifier.pmid16228050
dc.identifier.scopus2-s2.0-29144536169
dc.identifier.scopusqualityQ2
dc.identifier.startpage1529en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3428
dc.identifier.volume26en_US
dc.identifier.wosWOS:000233312300005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe immunohistochemical approach to determine the origin and possible function of the juxtaoral organ in dogsen_US
dc.typeArticle

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