Evaluation of the Effect of Different Inhalation Agents on Ovaries with Hyperthermic Intraperitoneal Chemotherapy: An Experimental Study

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dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridBASKAN, SEMIH/0000-0003-0096-7097
dc.contributor.authorSen, Ozlem
dc.contributor.authorAslan, Esra
dc.contributor.authorKalayci, Dilek
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorBaskan, Semih
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2025-01-21T16:40:44Z
dc.date.available2025-01-21T16:40:44Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground and Objectives: Cisplatin is a chemotherapeutic drug that is frequently used with hyperthermic intraperitoneal chemotherapy (HIPEC). Cisplatin-induced gonadotoxicity leads to a depletion of the ovarian reserve, causing premature ovarian insufficiency. This study aimed to investigate the impact of hyperthermia on cisplatin-induced ovarian toxicity and to determine whether sevoflurane or desflurane could be a more appropriate choice of anesthetic for reducing ovarian toxicity in HIPEC procedures. Materials and Methods: A total of 24 New Zealand rabbits were randomly divided into 4 groups as follows: Group H: HIPEC (cisplatin 7 mg/kg), Group HS: HIPEC (cisplatin 7 mg/kg) + 3% sevoflurane (2 h), Group HD: HIPEC (cisplatin 7 mg/kg) + 6% desflurane (2 h), and Group C: Control (Saline). Two catheters were placed in the abdominal cavity, the upper and lower quadrants. The perfusate was heated to 42 degrees C and given intraperitoneally for 90 min at a rate of 4 mL/min by catheters. Ovarian tissues were collected for Hematoxylin and Eosin staining and immunohistochemical analysis. Results: The primary follicle number was significantly decreased in Group H and HD compared to the C group (p < 0.05). Bax expression was high in Group H, according to all groups (p < 0.0001). Bax expression significantly decreased after sevoflurane, compared to group H (p = 0.012). The bcl-2 expression decreased in all groups compared to the C group. Bcl-2 expression was increased with sevoflurane compared to the H group (p = 0.001). Caspase 3 and p53 expression increased in all groups compared to the C group. p53 expression was decreased with sevoflurane and desflurane compared to the H group (p = 0.002, p = 0.008, respectively). Conclusions: The application of cisplatin with the intraoperative HIPEC method caused ovarian damage. According to our results, sevoflurane anesthesia could be a better option in mitigating cell death I the n ovarian reserve (follicle count) and apoptosis in the HIPEC procedures. We think that our findings should be supported by large series of clinical and experimental studies.
dc.identifier.doi10.3390/medicina60091403
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue9
dc.identifier.pmid39336444
dc.identifier.scopus2-s2.0-85205061629
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina60091403
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24757
dc.identifier.volume60
dc.identifier.wosWOS:001326417600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHIPEC; sevoflurane; desflurane; ovary; cisplatin; caspase 3; p53
dc.titleEvaluation of the Effect of Different Inhalation Agents on Ovaries with Hyperthermic Intraperitoneal Chemotherapy: An Experimental Study
dc.typeArticle

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