Efficacy of Curcumin in the healing of paracentesis in rats

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dc.contributor.authorBirdane, Leman
dc.contributor.authorSan, Turhan
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorBurukoglu, Dilek
dc.contributor.authorCingi, Cemal
dc.date.accessioned2020-06-25T18:12:20Z
dc.date.available2020-06-25T18:12:20Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: The present study was designed to investigate the possible beneficial effect of Curcumin (CMN) in healing of paracentesis in terms of wound thickness, sclerosis and closure by histological evaluation. To evaluate the efficacy of CMN, paracentesis was performed experimentally in the rats; and the results were presented histologically. Methods: Sixteen, each 270-310 g weighted, healthy Sprague-Dawley female rats were included into the study. In both groups, paracentesis was performed into the eardrum bilaterally. In Group 1 (Paracentesis + Saline Group), saline drop was applied; and in Group 2 (Paracentesis + Curcumin group), Curcumin drop treatment was applied. Paracentesis area did not healed bilaterally in two rats (one in Group 1 and one in Group 2). Therefore, these two rats were excluded from the study. Histological examination performed in 14 rats and 28 temporal bones on the 15th day after the completion of drop treatment and closure of the paracentesis-area and wound healing were evaluated according to the histological examination criteria: Thickening of the tympanic membrane (ThicTM); and sclerosis. Results: Both tympanic membrane thickening and sclerosis values of Paracentesis + Curcumin Group (Group 2) were significantly lower than those of the Paracentesis + Saline Group's (median: 2.0) (p = 0.001). Histological examination by light microscopy showed that in Paracentesis + Curcumin Group (Group 2), the structure of the tympanic membrane is near to the normal and decreased sclerosis was observed in connective tissue. Whereas in Paracentesis + Saline Group (Group 1), tympanic membrane thickening and connective tissue sclerosis were observed. Conclusions: Curcumin improves wound healing process in paracentesis of TM. By using Curcumin drops, the closured paracentesis area was observed near to the normal eardrum; and thickness of the TM and sclerosis were less than the control, showing the improved healing at 15th day. The possible mechanisms may be anti-inflammatory effect, improving collagen deposition, and increasing fibroblast and vascular density in wounds thereby enhancing impaired wound healing. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Associationen_US
dc.description.sponsorshipExcept data collection, preparation of this paper including designing and planning was supported by Continuous Education and Scientific Research Association.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ijporl.2013.11.024
dc.identifier.endpage284en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue2en_US
dc.identifier.pmid24355767
dc.identifier.scopus2-s2.0-84892477197
dc.identifier.scopusqualityQ2
dc.identifier.startpage280en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2013.11.024
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5869
dc.identifier.volume78en_US
dc.identifier.wosWOS:000330916100021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcumin (CMN) dropen_US
dc.subjectParacentesisen_US
dc.subjectRatsen_US
dc.subjectHistological examinationen_US
dc.titleEfficacy of Curcumin in the healing of paracentesis in ratsen_US
dc.typeArticle

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