Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats

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dc.contributor.authorArpaci, Hande
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorKosem, Bahadir
dc.contributor.authorKartal, Seyfi
dc.contributor.authorSivgin, Volkan
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2020-06-25T18:17:14Z
dc.date.available2020-06-25T18:17:14Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063; AYDIN, Muhammed Enes/0000-0001-8491-6566
dc.description.abstractBackground: Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under general anesthesia. It was shown that nonsteroidal anti-inflammatory drugs decrease erythrocyte deformability. Lornoxicam and/or intravenous (iv) ibuprofen are commonly preferred analgesic agents for postoperative pain management. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg, iv) and ibuprofen (30 mg/kg, iv) on erythrocyte deformability, as well as hepatic and renal blood flows, in male rats. Methods: Eighteen male Wistar albino rats were randomly divided into three groups as follows: iv lornoxicam-treated group (Group L), iv ibuprofen-treated group (Group I), and control group (Group C). Drug administration was carried out by the iv route in all groups except Group C. Hepatic and renal blood flows were studied by laser Doppler, and euthanasia was performed via intra-abdominal blood uptake. Erythrocyte deformability was measured using a constant-flow filtrometry system. Results: Lornoxicam and ibuprofen increased the relative resistance, which is an indicator of erythrocyte deformability, of rats (P=0.016). Comparison of the results from Group L and Group I revealed no statistically significant differences (P=0.694), although the erythrocyte deformability levels in Group L and Group I were statistically higher than the results observed in Group C (P=0.018 and P=0.008, respectively). Hepatic and renal blood flows were significantly lower than the same in Group C. Conclusion: We believe that lornoxicam and ibuprofen may lead to functional disorders related to renal and liver tissue perfusion secondary to both decreased blood flow and erythrocyte deformability. Further studies regarding these issues are thought to be essential.en_US
dc.description.sponsorshipGazi University Scientific Research Committee [01/2016-3]en_US
dc.description.sponsorshipThis study was supported by a grant from the Gazi University Scientific Research Committee (number 01/2016-3).en_US
dc.identifier.citationArpacı H, Çomu FM, Küçük A, Kösem B, Kartal S, Şıvgın V, Turgut HC, Aydın ME, Koç DS, Arslan M. Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats. Drug Des Devel Ther. 2016;10:2477-2481.en_US
dc.identifier.doi10.2147/DDDT.S113806
dc.identifier.endpage2481en_US
dc.identifier.issn1177-8881
dc.identifier.pmid27536068
dc.identifier.scopus2-s2.0-84983268283
dc.identifier.scopusqualityQ1
dc.identifier.startpage2477en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S113806
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6723
dc.identifier.volume10en_US
dc.identifier.wosWOS:000380738100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development And Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectraten_US
dc.subjectlornoxicamen_US
dc.subjectiv ibuprofenen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectblood flowen_US
dc.titleEffects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in ratsen_US
dc.typeArticle

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