Intestinal ischemia-reperfusion and plasma enzyme levels

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dc.contributor.authorÇağlayan, F.
dc.contributor.authorÇağlayan, O.
dc.contributor.authorGünel, E.
dc.contributor.authorElcuman, Y.
dc.contributor.authorÇakmak, M.
dc.date.accessioned2020-06-25T17:35:04Z
dc.date.available2020-06-25T17:35:04Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractDetermination of blood levels of intracellular enzymes is an appropriate method to evaluate tissue an organ damage. To show systemic tissue damage resulting from intestinal ischemia-reperfusion, New Zealand rabbits underwent 60 min intestinal ischemia and 60 min reperfusion. Plasma samples were obtained before and at 55, 70, and 120 min after operation and enzyme levels were determined. Plasma aspartate aminotransferase (AST) showed a significant increase during reperfusion while lactate dehydrogenase (LDH) and creatine kinase (CK) levels were significantly increased at the end of ischemia and continued to be so throughout reperfusion. It is difficult to claim that enzymes arise from the intestine, but an increase of CK, LDH. and later of AST without any increase in alanine aminotransferase levels during ischemia suggests that their primary source is the injured intestine. Increased levels of plasma enzymes do not provide exact information about the location, but do reveal the presence of an injury.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s003830100666
dc.identifier.endpage257en_US
dc.identifier.issn0179-0358
dc.identifier.issue4en_US
dc.identifier.pmid12021974
dc.identifier.scopus2-s2.0-0036589660
dc.identifier.scopusqualityQ2
dc.identifier.startpage255en_US
dc.identifier.urihttps://doi.org/10.1007/s003830100666
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3010
dc.identifier.volume18en_US
dc.identifier.wosWOS:000176221700010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintestinal ischemia-reperfusionen_US
dc.subjectplasma enzyme levelsen_US
dc.titleIntestinal ischemia-reperfusion and plasma enzyme levelsen_US
dc.typeArticle

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