Can curcumin modulate allergic rhinitis in rats?

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dc.contributor.authorAcar, M.
dc.contributor.authorMuluk, N. Bayar
dc.contributor.authorYigitaslan, S.
dc.contributor.authorCengiz, B. P.
dc.contributor.authorShojaolsadati, P.
dc.contributor.authorKarimkhani, H.
dc.contributor.authorCingi, C.
dc.date.accessioned2020-06-25T18:16:00Z
dc.date.available2020-06-25T18:16:00Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionkarimkhani, Hadi/0000-0002-4966-1745; Shojaolsadati, Paria/0000-0001-8311-5425
dc.description.abstractObjectives: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. Methods: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21-28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21-28. Allergy symptoms and histopathological features of the nasal mucosa were examined. Results: The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria. Conclusion: Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Association, Turkeyen_US
dc.description.sponsorshipStudy design and planning and manuscript preparation were supported by the Continuous Education and Scientific Research Association, Turkey.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1017/S0022215116008999
dc.identifier.endpage1109en_US
dc.identifier.issn0022-2151
dc.identifier.issn1748-5460
dc.identifier.issue12en_US
dc.identifier.pmid27707425
dc.identifier.scopus2-s2.0-84990200315
dc.identifier.scopusqualityQ2
dc.identifier.startpage1103en_US
dc.identifier.urihttps://doi.org/10.1017/S0022215116008999
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6380
dc.identifier.volume130en_US
dc.identifier.wosWOS:000391446800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal Of Laryngology And Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectRhinitisen_US
dc.subjectAllergicen_US
dc.subjectPerennialen_US
dc.subjectRatsen_US
dc.titleCan curcumin modulate allergic rhinitis in rats?en_US
dc.typeArticle

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