Deficits in peripheric and central olfactory measurements in smokers: evaluated by cranial MRI

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dc.authoridBekin Sarikaya, Pelin Zeynep/0000-0001-9588-6702
dc.authoridBAYAR MULUK, NURAY/0000-0003-3602-9289
dc.contributor.authorSarikaya, Pelin Zeynep Bekin
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorBaser, Selcuk
dc.contributor.authorOzdemir, Adnan
dc.contributor.authorYilmazsoy, Yunus
dc.date.accessioned2025-01-21T16:37:17Z
dc.date.available2025-01-21T16:37:17Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives Cigarette smoking remains a serious health problem all over the world. We investigated the peripheral and central olfactory pathways in young male smokers to determine whether there is a relationship between the amount of cigarettes smoked and duration of smoking and the dimensions of the olfactory areas. Methods In this retrospective study, cranial Magnetic Resonance Imaging (MRI) images of adult male smokers aged <= 40 years (n = 51) and 50 healthy male adults were analyzed. The olfactory bulbus (OB) volumes and olfactory sulcus (OS) depths, insular gyrus, and corpus amygdala areas were measured via cranial MRI. In the smoker group, the number of cigarettes smoked and duration of smoking were noted and the Brinkmann index was calculated. Results OB volume, OS depth, and the insular gyrus areas of the smokers were lower than in the control group (p < 0.05). There were no differences between the groups in terms of the corpus amygdala measurements (p > 0.05). No significant correlations were found between the number of cigarettes smoked daily, smoking duration, and the Brinkmann index and the peripheral and central olfactory measurements in our study (p > 0.05). Conclusions In smokers, OB volumes, the OS, and the central areas decrease bilaterally, regardless of smoking duration and number of cigarettes smoked daily. This could be related to inflammatory mediators that may be harmful to the olfactory neuroepithelium, gray matter atrophy in the brain, or endothelial damage related to smoking and its effects on blood support to the brain and olfactory regions.
dc.identifier.doi10.1007/s00405-022-07700-4
dc.identifier.endpage1271
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue3
dc.identifier.pmid36242611
dc.identifier.scopus2-s2.0-85140065841
dc.identifier.scopusqualityQ1
dc.identifier.startpage1265
dc.identifier.urihttps://doi.org/10.1007/s00405-022-07700-4
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24445
dc.identifier.volume280
dc.identifier.wosWOS:000868369600004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectSmell; Cranial MRI; OB volume; OS depth; Insular gyrus area; Corpus amygdala area; Smoking; Brinkmann index
dc.titleDeficits in peripheric and central olfactory measurements in smokers: evaluated by cranial MRI
dc.typeArticle

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