Production and characterization of bactericidal wound dressing material based on gelatin nanofiber

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dc.contributor.authorInal, Murat
dc.contributor.authorMulazimoglu, Gokce
dc.date.accessioned2020-06-25T18:30:35Z
dc.date.available2020-06-25T18:30:35Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractGelatin is a biocompatible and biodegradable natural polymer obtained by collagen. Gelatin nanofibers meet all the necessary requirements when used as wound dressing material. However, their lack of antimicrobial properties limits their use. The purpose of this study is to expand the field of use of gelatin by providing it with antimicrobial properties. For this purpose, poly([2-(methacryloyloxy)ethyl] trimethylammonium chloride) (PMETAC), was used. In this study, the polymers were dissolved in formic acid-acetic acid and nanofibers were synthesized by electrospinning. The obtained nanofibers were characterized with SEM, FTIR, and TGA. The antibacterial effect, degradation tests, and cell viability, adhesion and proliferation were investigated. The SEM studies show that the nanofibers are homogeneous and smooth. At the end of 14 days, all nanofibers lost >90% of their mass. The nano fibers containing PMETAC showed good bactericidal activity against Staphylococcus aureus, Escherichia coli, methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii. mTT test demonstrated that low doses of the nanofibers were biocompatible. The cell adhesion study has been shown that many cells attachment and proliferate on the surface of nanofibers. It has been found that the obtained nanofibers can be used safely and effectively as antimicrobial wound dressing material. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Unit, Kirikkale, TurkeyKirikkale University [2014/062, 2016/030]en_US
dc.description.sponsorshipThe authors are grateful to the Kirikkale University Scientific Research Projects Unit, Kirikkale, Turkey for their support (Project Numbers; 2014/062 and 2016/030).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ijbiomac.2019.06.119
dc.identifier.endpage404en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid31233795
dc.identifier.scopus2-s2.0-85068390432
dc.identifier.scopusqualityQ1
dc.identifier.startpage392en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.06.119
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7683
dc.identifier.volume137en_US
dc.identifier.wosWOS:000484644100044
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal Of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectrospinningen_US
dc.subjectGelatinen_US
dc.subjectNanofiberen_US
dc.subject[2-(Methaayloyloxy)ethyl] trimethylammonium chloride)en_US
dc.subjectWound dressingen_US
dc.titleProduction and characterization of bactericidal wound dressing material based on gelatin nanofiberen_US
dc.typeArticle

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