Comparison of clinical outcomes and FOXP3, IL-17A responses in Helicobacter pylori infection in children versus adults

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dc.contributor.authorYorguc, Eda
dc.contributor.authorGulerman, Hacer Fulya
dc.contributor.authorKalkan, Ismail Hakki
dc.contributor.authorGuven, Burcu
dc.contributor.authorBalci, Mahi
dc.contributor.authorYorguc, Mustafa caglar
dc.date.accessioned2025-01-21T16:36:46Z
dc.date.available2025-01-21T16:36:46Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground The purpose of this study was to compare the clinical symptoms and pathological consequences of Helicobacter pylori (H. pylori) infection between children and adults and determine the levels of expression of FOX3P and IL-17A to examine the Th17/Treg balance. Methods Forty pediatric and 40 adult patients who were followed up at the Pediatric Gastroenterology and Internal Medicine Gastroenterology Departments were enrolled in the study. In our case-control study, gastric tissue specimens were evaluated using the updated Sydney system, and the number of cells expressing FOXP3/IL-17A (T-reg and Th17 cell markers) was analyzed immunohistochemically. In addition, each case was evaluated using a clinical follow-up questionnaire. Results Clinical signs and symptoms of children and adults were similar. IL-17A and FOXP3 levels were significantly higher in children and adults with H. pylori (+) than in those without H. pylori (-) (p < .001). In patients with H. pylori (+), the mean FOXP3 level was significantly higher, whereas the mean IL-17A level was significantly lower in children than in adults (p < 0001 for both groups). In children with H. pylori (+), bacterial density was negatively correlated with IL-17A level and positively correlated with FOXP3 level. In adults with H. pylori (+), there was a statistically significant, highly positive correlation between bacterial density and levels of IL-17A and FOXP3. Conclusions T-reg cells are suggested to more predominant in children than in adults, IL-17A levels decrease as H. pylori bacterial density increases. In conclusion, immune responses incline toward T-reg, which increases the susceptibility to persistent infections.
dc.description.sponsorshipKirikkale University Scientific Research Project Center
dc.description.sponsorshipThe study was supported by Kirikkale University Scientific Research Project Center.
dc.identifier.doi10.1111/hel.12795
dc.identifier.issn1083-4389
dc.identifier.issn1523-5378
dc.identifier.issue3
dc.identifier.pmid33818871
dc.identifier.scopus2-s2.0-85103549800
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/hel.12795
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24383
dc.identifier.volume26
dc.identifier.wosWOS:000636692200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofHelicobacter
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectFOXP3; Helicobacter pylori; IL? 17A; Th17; Treg balance
dc.titleComparison of clinical outcomes and FOXP3, IL-17A responses in Helicobacter pylori infection in children versus adults
dc.typeArticle

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