Effect of sildenafil citrate treatment on serum dehydroepiandrosterone sulfate levels in patients with erectile dysfunction

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dc.contributor.authorTekdoğan, Ümit
dc.contributor.authorTuncel, Altuğ
dc.contributor.authorTuglu, Devrim
dc.contributor.authorBasar, M. Murad
dc.contributor.authorAtan, Ali
dc.date.accessioned2020-06-25T17:43:29Z
dc.date.available2020-06-25T17:43:29Z
dc.date.issued2006
dc.description.abstractObjectives. To investigate the effect of sildenafil citrate treatment on serum dehydroepiandrosterone sulfate (DHEAS) levels in patients with erectile dysfunction (ED). Methods. A total of 124 men with a mean age of 45.9 years were included in the study. Group 1 consisted of 78 patients with ED, as determined by the Sexual Health Inventory of Male (SHIM) scale (score less than 2 1). Group 2 consisted of 46 healthy men with a SHIM score of 21 or greater. The 78 patients with ED took 100 mg sildenafil citrate at least eight times in 1 month. The SHIM scale was administered and serum DHEAS levels measured before and after treatment in the ED group. The serum DHEAS levels were also measured in the control group. The treatment response was defined as positive if the SHIM score was 21 or greater after sildenafil administration. Results. At the end of sildenafil citrate treatment, the serum DHEAS levels and SHIM scores had increased significantly in the ED group (P = 0.013 and P = 0.001, respectively). In groups 1 and 2, the mean pretreatment serum DHEAS level of the men younger than 50 years old was 200.1 +/- 77.9 and 279.4 +/- 125.4 mu g/dL, respectively (P = 0.013). The elevation of the serum DHEAS levels and SHIM scores was more significant in the sildenafil responders (P = 0.002 and P = 0.001), respectively. Conclusions. Serum DHEAS levels were significantly greater in the patients younger than 50 years old than in the older patients in the ED group. The serum DHEAS levels increased significantly after sildenafil citrate treatment in the ED group (especially in the younger men). Also, patient age was an important factor affecting the sildenafil citrate response.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.urology.2006.03.019
dc.identifier.endpage630en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue3en_US
dc.identifier.pmid16979704
dc.identifier.scopus2-s2.0-33748945706
dc.identifier.scopusqualityQ2
dc.identifier.startpage626en_US
dc.identifier.urihttps://doi.org10.1016/j.urology.2006.03.019
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3728
dc.identifier.volume68en_US
dc.identifier.wosWOS:000241721600038
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of sildenafil citrate treatment on serum dehydroepiandrosterone sulfate levels in patients with erectile dysfunctionen_US
dc.typeArticle

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