Investigation of the Effectiveness of Nasal Sprays in Allergic Rhinitis

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dc.authoridGUNER ATAYOGLU, AYTEN/0000-0002-1759-7339
dc.contributor.authorAtayoglu, Ayten Guner
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorKoca, Rahime
dc.contributor.authorCukurova, Ibrahim
dc.contributor.authorCetinkaya, Erdem Atalay
dc.contributor.authorYoruk, Ozgur
dc.contributor.authorBal, Cengiz
dc.date.accessioned2025-01-21T16:42:11Z
dc.date.available2025-01-21T16:42:11Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We investigated the effectiveness of different types of nasal irrigation sprays in adult allergic rhinitis (AR) patients. Methods: A total of 1700 patients with AR (866 males and 834 females) were assigned to: Group 1: Hypertonic nasal spray group (n = 600) (Sinomarin (R) hypertonic nasal spray); Group 2: Algae-containing hypertonic nasal spray group (n = 600) (Sinomarin Plus Algae ENT); and Group 3: Isotonic saline nasal spray group (n = 500). All patients underwent an otolaryngological examination, continued their standard AR treatment, and received the assigned nasal spray additionally (1 spray to each nostril, 3 times a day, for 3 weeks). Allergic symptom scores, turbinate examination, total symptom scores, and quality of life (QoL) scores were evaluated during pre- and post-treatment periods. Results: In groups 1 and 2, symptom scores and turbinate color and edema, total symptom scores, and QoL scores increased after treatment (P < .05). In the saline group, there were no significant differences in symptom scores and total symptom scores after treatment; however, improvement was detected in turbinate color and edema values after treatment. QoL scores increased after treatment. When comparing the 3 groups, the total symptom scores of groups 1 and 2 were significantly lower, and the QoL scores of groups 1 and 2 were considerably higher than those of the saline group. There were no significant differences between groups 1 and 2. Conclusion: Algae-containing and hypertonic nasal spray may be added to the standard AR treatment to increase QoL and decrease total symptom scores.
dc.description.sponsorshipClinical Research Organization, Turkey
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial sup-port for the research, authorship, and/or publication of this article: The Clinical Research Organization, Turkey provided all nasal sprays used in this study. However, this organization did not solicit the investigators or institutions' research proj-ects or protocols.
dc.identifier.doi10.1177/01455613241287298
dc.identifier.endpage151S
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue3_SUPPL
dc.identifier.pmid39390797
dc.identifier.scopus2-s2.0-85206446274
dc.identifier.scopusqualityQ2
dc.identifier.startpage144S
dc.identifier.urihttps://doi.org/10.1177/01455613241287298
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25006
dc.identifier.volume103
dc.identifier.wosWOS:001336370300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectalgae-containing hypertonic nasal spray; hypertonic nasal spray; isotonic saline nasal spray; allergic rhinitis; total symptom scores; quality of life scores
dc.titleInvestigation of the Effectiveness of Nasal Sprays in Allergic Rhinitis
dc.typeArticle

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