Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types

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dc.contributor.authorKilicay, Ebru
dc.contributor.authorErdal, Ebru
dc.contributor.authorHazer, Baki
dc.contributor.authorTurk, Mustafa
dc.contributor.authorDenkbas, Emir Baki
dc.date.accessioned2020-06-25T18:16:03Z
dc.date.available2020-06-25T18:16:03Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionBayram, Cem/0000-0001-8717-4668
dc.description.abstractAmphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. For this purpose, PHB-b-PEG-NH2 block copolymers were synthesized via transesterification reactions. The copolymers obtained were characterized by Proton Nuclear Magnetic Resonance (H-1-NMR), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC) techniques. The cytotoxic, apoptotic and necrotic effects of these nanoparticles in the MDA 231 human breast cancer cell, the A549 human lung cancer cell and the L929 fibroblast cell lines were also investigated.en_US
dc.description.sponsorshipBulent Ecevit University Research FundBulent Ecevit University [BEU-2012-M6-00-03]en_US
dc.description.sponsorshipThis work was financially supported by the Bulent Ecevit University Research Fund (Grant no. BEU-2012-M6-00-03).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/21691401.2015.1115409
dc.identifier.endpage1948en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue8en_US
dc.identifier.pmid26613393
dc.identifier.scopus2-s2.0-84989916587
dc.identifier.scopusqualityQ1
dc.identifier.startpage1938en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2015.1115409
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6401
dc.identifier.volume44en_US
dc.identifier.wosWOS:000385745200019
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine And Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntisense oligonucleotideen_US
dc.subjectfibroblast cellsen_US
dc.subjecthuman breast cancer cellsen_US
dc.subjecthuman lung cancer cellsen_US
dc.subjectPHB-PEG block copolymeren_US
dc.subjectPHB-PEG nanoparticleen_US
dc.titleAntisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer typesen_US
dc.typeArticle

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