The effects of experimental aflatoxicosis on the exocrine pancreas in quails (Coturnix coturnix japonica)

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dc.contributor.authorŞimşek, Nejdet
dc.contributor.authorErgun, Levent
dc.contributor.authorErgun, Emel
dc.contributor.authorAlabay, Belma
dc.contributor.authorEssiz, Dinc
dc.date.accessioned2020-06-25T17:43:40Z
dc.date.available2020-06-25T17:43:40Z
dc.date.issued2007
dc.descriptionEssiz, Dinc/0000-0002-4759-7858
dc.description.abstractThe present investigation was undertaken to assess the effects of aflatoxin (AF) on the exocrine pancreas in quails by means of light and electron microscopy. A total of 30 quails were divided into three groups, each composed of ten animals. Total AF was incorporated into the diet of these groups, at doses of 0, 2.5, and 5.0 mg of AF/kg feed, ppm, respectively. The quails were raised in cages with electrical heating and 24-h lighting for a period of 3 weeks. Ad libitum access was provided to feed and drinking water. Pancreas samples were taken for light and electron microscopic examination from animals that were killed by means of cervical dislocation at the end of the study. Light microscopic examination demonstrated mild mononuclear cell infiltration of exocrine tissue and vacuolisation of acinar cells in the group fed on AF at 2.5 ppm. On the other hand, electron microscopic examination demonstrated degranulation of the rough endoplasmic reticulum (rER) of acinar cells, decrease in the number of zymogen granules and free ribosomes and polisomes, and dilatation of capillaries in the group fed on AF at a dose of 2.5 ppm. Numerous degenerative acinar cells were determined in the group fed a diet containing 5.0 ppm AF, in addition to the findings common with the other group exposed to the toxin.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00204-007-0205-6
dc.identifier.endpage588en_US
dc.identifier.issn0340-5761
dc.identifier.issn1432-0738
dc.identifier.issue8en_US
dc.identifier.pmid17486318
dc.identifier.scopus2-s2.0-34447528679
dc.identifier.scopusqualityQ1
dc.identifier.startpage583en_US
dc.identifier.urihttps://doi.org10.1007/s00204-007-0205-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3848
dc.identifier.volume81en_US
dc.identifier.wosWOS:000248109400006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaflatoxinen_US
dc.subjectexocrine pancreasen_US
dc.subjectquailen_US
dc.titleThe effects of experimental aflatoxicosis on the exocrine pancreas in quails (Coturnix coturnix japonica)en_US
dc.typeArticle

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