Does maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats?

Basit Öğe Kaydı
dc.contributor.authorBasak, K.
dc.contributor.authorBasak, P. Y.
dc.contributor.authorDoguc, D. K.
dc.contributor.authorAylak, F.
dc.contributor.authorOguztuzun, S.
dc.contributor.authorBozer, B. M.
dc.contributor.authorGultekin, F.
dc.date.accessioned2020-06-25T18:22:41Z
dc.date.available2020-06-25T18:22:41Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.descriptionBASAK, KAYHAN/0000-0003-1960-8924; Gultekin, Fatih/0000-0003-2888-3215; Bozer, Busra/0000-0002-7280-4417
dc.description.abstractGlutathione-S-transferase (GST) and cytochrome P450 family 1 subfamily A polypeptide 1 (CYP1A1) metabolize and detoxify carcinogens, drugs, environmental pollutants, and reactive oxygen species. Changes of GST expression in tissues and gene mutations have been reported in association with many neoplastic skin diseases and dermatoses. Widely used artificial food coloring additives (AFCAs) also reported to effect primarily behavioral and cognitive function and cause neoplastic diseases and several inflammatory skin diseases. We aimed to identify the changes in expression of GSTs, CYP1A1, and vascular endothelial growth factor (VEGF) in rat skin which were maternally exposed AFCAs. A rat model was designed to evaluate the effects of maternal exposure of AFCAs on skin in rats. No observable adverse effect levels of commonly used AFCAs as a mixture were given to female rats before and during gestation. Immunohistochemical expression of GSTs, CYP1A1, and VEGF was evaluated in their offspring. CYP1A1, glutathione S-transferase pi (GSTP), glutathione S-transferase alpha (GSTA), glutathione S-transferase mu (GSTM), glutathione S-transferase theta (GSTT), and VEGF were expressed by epidermal keratinocytes, dermal fibroblasts, sebaceous glands, hair follicle, and subcutaneous striated muscle in the normal skin. CYP1A1, GSTA, and GSTT were expressed at all microanatomical sites of skin in varying degrees. The expressions of CYP1A1, GSTA, GSTT, and VEGF were decreased significantly, while GSTM expression on sebaceous gland and hair follicle was increased. Maternal exposure of AFCAs apparently effects expression of the CYP1A1, GSTs, and VEGF in the skin. This prominent change of expressions might play role in neoplastic and nonneoplastic skin diseases.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1177/0960327116678297
dc.identifier.endpage1030en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue10en_US
dc.identifier.pmid27852938
dc.identifier.startpage1023en_US
dc.identifier.urihttps://doi.org/10.1177/0960327116678297
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6866
dc.identifier.volume36en_US
dc.identifier.wosWOS:000411222500004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFood coloring additivesen_US
dc.subjectgenotoxicityen_US
dc.subjectglutathione-S-transferaseen_US
dc.subjectoxidative stressen_US
dc.subjectskin diseaseen_US
dc.titleDoes maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats?en_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Does maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats.pdf
Boyut:
488.15 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu