The Effect of Sevoflurane and Fullerenol C 60 on the Liver and Kidney in Lower Extremity Ischemia-Reperfusion Injury in Mice with Streptozocin-Induced Diabetes

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dc.authoridOzdemir, Cagri/0000-0002-1266-8054
dc.authoridDURSUN, ALI DOGAN/0000-0001-9056-0025
dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridEr, Fatma/0000-0003-3008-1764
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridSengel, Necmiye/0000-0001-8591-3658
dc.contributor.authorSengel, Necmiye
dc.contributor.authorKucuk, Ayseguel
dc.contributor.authorOzdemir, Cagri
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorKip, Gulay
dc.contributor.authorEr, Fatma
dc.contributor.authorDursun, Ali Dogan
dc.date.accessioned2025-01-21T16:45:20Z
dc.date.available2025-01-21T16:45:20Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: This study aimed to demonstrate whether fullerenol C60, sevoflurane anesthesia, or a combination of both had protective effects on the liver and kidneys in lower extremity ischemia-reperfusion injury (IRI) in mice with streptozocin-induced diabetes. Methods: A total of 46 Swiss albino mice were divided into six groups as follows: control group (group C, n=7), diabetes group (group D, n=7), diabetes-ischemia/reperfusion (group DIR, n=8), diabetes-ischemia/reperfusion-fullerenol C60 (group DIR-FC60, n=8), diabetes-ischemia/reperfusion-sevoflurane (group DIR-S, n=8), and the diabetes-ischemia/reperfusion-fullerenol C60-sevoflurane (group DIR-S-FC60, n=8). Fullerenol C60 (100mg/kg) was administered intraperitoneally 30 min before the ischemia-reperfusion procedure to the fullerenol groups (DIR-FC60 and DIR-S-FC60). In the DIR groups, 2 hours (h) ischemia-2h reperfusion periods were performed. In the sevoflurane groups, sevoflurane was applied during the ischemia-reperfusion period with 100% O2. Liver and kidney tissues were removed at the end of the reperfusion procedure for biochemical and histopathological examinations.Results: In liver tissue, hydropic degeneration, sinusoidal dilatation, pycnotic nuclei, prenecrotic cells, and mononuclear cell infiltration in parenchyma were significantly more frequent in group DIR than in groups D and group C. In terms of the histopathologic criteria examined, more positive results were seen in group DIR-FC60, and when group DIR-FC60 was compared with group DIR, the difference was significant. The best results in AST, ALT, glucose, TBARS levels, and SOD enzyme activities in liver tissue were in group DIR-FC60 compared with group DIR, followed by groups DIR-S-FC60 and DIR-S, respectively. Regarding TBARS levels and SOD enzyme activities in kidney tissue, the best results were in groups DIR-FC60, DIR-S-FC60, and DIR-S, respectively.Conclusion: According to our findings, it is clear that fullerenol C60 administered intraperitoneally 30 min before ischemia, alone or together with sevoflurane, reduces oxidative stress in distant organ damage caused by lower extremity IRI, and reduces liver and kidney tissue damage in histopathologic examinations.
dc.description.sponsorshipGazi University BAP coordination unit [TCD- 2022-8210]
dc.description.sponsorshipThis study was supported by the Gazi University BAP coordination unit within the scope of this project numbered TCD- 2022-8210.
dc.identifier.doi10.2147/IJN.S432924
dc.identifier.endpage7557
dc.identifier.issn1178-2013
dc.identifier.pmid38111848
dc.identifier.scopus2-s2.0-85179692754
dc.identifier.scopusqualityQ1
dc.identifier.startpage7543
dc.identifier.urihttps://doi.org/10.2147/IJN.S432924
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25616
dc.identifier.volume18
dc.identifier.wosWOS:001125067900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofInternational Journal of Nanomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectlower extremity; ischemia-reperfusion; diabetes; fullerenol C60; sevoflurane; kidney; liver; mice
dc.titleThe Effect of Sevoflurane and Fullerenol C 60 on the Liver and Kidney in Lower Extremity Ischemia-Reperfusion Injury in Mice with Streptozocin-Induced Diabetes
dc.typeArticle

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