The activities of GST isozymes in stomach tissues of female obese patients

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dc.contributor.authorYilmaz C.
dc.contributor.authorBulus H.
dc.contributor.authorOguztuzun S.
dc.contributor.authorCihan M.
dc.contributor.authorFidan C.
dc.date.accessioned2021-01-14T18:11:16Z
dc.date.available2021-01-14T18:11:16Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractObjectives: Obesity has become an important public health problem because of its increasing prevalence and relation with many diseases and mortality. Studies have shown its association with oxidative stress. In this study, the effect of obesity on total amount of thiol and some glutathione S-transferase (GST) isozymes were investigated which could serve as an important criteria in dose adjustment of some certain drugs in obese. Methods: The gastric tissues removed by gastrectomy operation from 29 morbid obese female patients were analysed for thiol levels and activities of total GST, GSTT1-1 and GSTM1-1. Patients were grouped according to age, presence of hypertension and/or diabetes, and family history. Results: The average total thiol was 131.22 (±7.74) nmol/ mg protein with no significant differences in between the groups. GSTT1 specific activities were about 20% higher in four groups: with ages over 35 years old, with hypertension, without diabetes and finally without family history, with respect to other groups. The differences between total GST and GSTM1 activity levels of experimental groups were not significant. Conclusions: This is the first study to compare activities of GST isozymes and total thiol content in the stomach tissues of obese female patients accompanying some common metabolic disorders, age and family history. © 2020 De Gruyter. All rights reserved.en_US
dc.identifier.doi10.1515/tjb-2020-0235
dc.identifier.endpage889en_US
dc.identifier.issn0250-4685
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85098981794
dc.identifier.scopusqualityQ3
dc.identifier.startpage883en_US
dc.identifier.trdizinid455328
dc.identifier.urihttps://doi.org/10.1515/tjb-2020-0235
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12934
dc.identifier.volume45en_US
dc.identifier.wosWOS:000603517600031
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherDe Gruyter Open Ltden_US
dc.relation.ispartofTurkish Journal of Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectGastrectomyen_US
dc.subjectGSTen_US
dc.subjectHypertensionen_US
dc.subjectObesityen_US
dc.subjectTotal thiolen_US
dc.titleThe activities of GST isozymes in stomach tissues of female obese patientsen_US
dc.typeArticle

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