The Role of Matrix Metalloproteinase-2 Promoter Polymorphisms in Coronary Artery Disease and Myocardial Infarction

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dc.contributor.authorAlp, Ebru
dc.contributor.authorMenevse, Sevda
dc.contributor.authorTulmac, Murat
dc.contributor.authorYilmaz, Akin
dc.contributor.authorYalcin, Ridvan
dc.contributor.authorCengel, Atiye
dc.date.accessioned2020-06-25T17:51:55Z
dc.date.available2020-06-25T17:51:55Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionYILMAZ, AKIN/0000-0002-4368-0777
dc.description.abstractThe matrix metalloproteinase (MMP) family are key enzymes involved in the breakdown of the extracellular matrix in normal physiological processes, including tissue remodeling, and disease processes, such as arthritis and metastasis. The promoter polymorphism in the MMP2 gene may be responsible for multiple diseases related to extracellular matrix degradation. Therefore, we aimed to investigate the relationship between genotypes or haplotypes of -1575 G/A, -1306 C/T, -790 T/G, and -735 C/T promoter polymorphisms and coronary artery disease (CAD) with or without myocardial infarction (MI) history. This study included 298 patients with angiographically confirmed CAD and 299 age matched controls. Genomic DNA was isolated from whole blood and genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. No significant associations were found between -1575 G/A, -1306 C/T, and -790 T/G polymorphisms and CAD with or without MI history. However, the frequency of the -735 TT genotype was significantly lower in the controls than in the patients with MI alone when compared with the CC genotype (p = 0.021). Only the distribution of the ACGC haplotype in CAD patients exhibited a significant difference than that in controls (p < 0.05). The distribution of other haplotypes did not differ between CAD patients and controls. The present investigation is the first report to detect an association between MMP2 promoter polymorphisms and CAD with or without MI history in the Turkish population. Further case-control studies in CAD development might be contributed to clarify the role of these polymorphisms.en_US
dc.description.sponsorshipGazi UniversityGazi University [11/2004-84]en_US
dc.description.sponsorshipThis study was partially supported by the Gazi University Research Fund as a project with code number 11/2004-84.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1089/gtmb.2010.0113
dc.identifier.endpage202en_US
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue4en_US
dc.identifier.pmid21142815
dc.identifier.scopus2-s2.0-79953069202
dc.identifier.scopusqualityQ3
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2010.0113
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5031
dc.identifier.volume15en_US
dc.identifier.wosWOS:000288850800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofGenetic Testing And Molecular Biomarkers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe Role of Matrix Metalloproteinase-2 Promoter Polymorphisms in Coronary Artery Disease and Myocardial Infarctionen_US
dc.typeArticle

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