Effects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizure

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dc.contributor.authorEsmekaya, Meric Arda
dc.contributor.authorTuysuz, Mehmet Zahid
dc.contributor.authorTomruk, Arin
dc.contributor.authorCanseven, Ayse G.
dc.contributor.authorYucel, Engin
dc.contributor.authorAktuna, Zuhal
dc.contributor.authorSeyhan, Nesrin
dc.date.accessioned2020-06-25T18:16:17Z
dc.date.available2020-06-25T18:16:17Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionTuysuz, Mehmet/0000-0002-2650-5475; Tomruk, Arin/0000-0002-7600-0811
dc.description.abstractThe objective of the this study was to evaluate the effects of cellular phone radiation on oxidative stress parameters and oxide levels in mouse brain during pentylenetetrazole (PTZ) induced epileptic seizure. Eight weeks old mice were used in the study. Animals were distributed in the following groups: Group I: Control group treated with PTZ, Group II: 15 min cellular phone radiation + PTZ treatment + 30 min cellular phone radiation, Group III: 30 min cellular phone radiation + PTZ treatment + 30 min cellular phone radiation. The RF radiation was produced by a 900 MHz cellular phone. Lipid peroxidation, which is the indicator of oxidative stress was quantified by measuring the formation of thiobarbituric acid reactive substances (TBARS). The glutathione (GSH) levels were determined by the Ellman method. Tissue total nitric oxide (NOx) levels were obtained using the Griess assay. Lipid peroxidation and NOx levels of brain tissue increased significantly in group II and III compared to group I. On the contrary, GSH levels were significantly lower in group II and III than group I. However, no statistically significant alterations in any of the endpoints were noted between group II and Group III. Overall, the experimental findings demonstrated that cellular phone radiation may increase the oxidative damage and NOx level during epileptic activity in mouse brain. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipGazi University Research FoundationGazi University [01/2003-62]en_US
dc.description.sponsorshipEM Field measurements were performed with the devices purchased by a grant from the Gazi University Research Foundation Project No: 01/2003-62.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jchemneu.2016.01.011
dc.identifier.endpage115en_US
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.pmid26836107
dc.identifier.scopus2-s2.0-84989773552
dc.identifier.scopusqualityQ3
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2016.01.011
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6478
dc.identifier.volume75en_US
dc.identifier.wosWOS:000381842500011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal Of Chemical Neuroanatomy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSeizureen_US
dc.subjectPentylenetetrazoleen_US
dc.subjectMiceen_US
dc.subjectCell phoneen_US
dc.subjectRadiationen_US
dc.titleEffects of cell phone radiation on lipid peroxidation, glutathione and nitric oxide levels in mouse brain during epileptic seizureen_US
dc.typeArticle

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