Comparison of Intratympanic Oxytocin and Dexamethasone in Cisplatin Ototoxicity: An Experimental Study

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dc.authoridTAS, BURAK MUSTAFA/0000-0002-1983-5329
dc.contributor.authorTas, Burak Mustafa
dc.contributor.authorOzel, Goekce
dc.contributor.authorAzman, Musa
dc.contributor.authorcakmak Karaer, Isil
dc.contributor.authorKilic, Rahmi
dc.date.accessioned2025-01-21T16:36:48Z
dc.date.available2025-01-21T16:36:48Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAlthough it is widely used, there is still no valid treatment for ototoxicity caused by the antineoplastic drug cisplatin. In this study, we aimed to investigate the efficacy of intratympanic resveratrol and intratympanic dexamethasone treatment in cisplatin-induced ototoxicity. We also compared intratympanic atosiban (oxytocin antagonist) and oxytocin in cisplatin ototoxicity. In this study, 30 rats (60 ears) were used by separating into 5 groups. Cisplatin, oxytocin, dexamethasone, atosiban and 0.9% NaCl were administered intraperitoneally to all groups separately. Auditory Brainstem Response and Distortion Product Otoacoustic Emission tests were performed on all groups before and 72 h after the procedure. Pre-treatment values were higher than post-treatment values in all groups (p < 0.001). There was no significant prolongation of the post-treatment Auditory Brainstem Response I-IV interval in the oxytocin and dexamethasone groups (p > 0.05). There was no significant decrease in the frequencies of 2832 and 4004 after treatment in the oxytocin and dexamethasone group compared to pre-treatment in Distortion Product Otoacoustic Emission. As a result, it has been shown that intratympanic oxytocin may be an option that can be used in the treatment, although it is not as effective as dexamethasone in preventing cisplatin ototoxicity.
dc.identifier.doi10.1007/s12070-024-04701-z
dc.identifier.endpage3411
dc.identifier.issn2231-3796
dc.identifier.issn0973-7707
dc.identifier.issue4
dc.identifier.pmid39130317
dc.identifier.scopus2-s2.0-85191144109
dc.identifier.scopusqualityQ3
dc.identifier.startpage3405
dc.identifier.urihttps://doi.org/10.1007/s12070-024-04701-z
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24387
dc.identifier.volume76
dc.identifier.wosWOS:001207647300002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer India
dc.relation.ispartofIndian Journal of Otolaryngology and Head & Neck Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAtosiban; Cisplatin; Dexamethasone; Ototoxicity; Oxytocin
dc.titleComparison of Intratympanic Oxytocin and Dexamethasone in Cisplatin Ototoxicity: An Experimental Study
dc.typeArticle

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