Prognostic role of tumour-infiltrating T lymphocytes in stage IIA (T3N0) colon cancer: A broad methodological study in a fairly homogeneous population

Basit Öğe Kaydı
dc.contributor.authorZengin, Melunet
dc.date.accessioned2020-06-25T18:30:46Z
dc.date.available2020-06-25T18:30:46Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Tumour-infiltrating T lymphocytes (TIL) are considered to be a reliable prognostic marker in CC, but the use in daily practice is unclear. We investigated the survival effect of TIL methodologically in a highly homogeneous population. Methods: Seventy-two stage IIA (T3N0) CC patients who underwent surgical resection from 2000 to 2014 were included. CD3 and CD8 were separately scored for different blocks, areas and foci. To the best of our knowledge, this study has the most comprehensive methodology in the literature. Results: Foremost, we searched for the optimal evaluation method. We found better results with Model A (deepest invasive block&hot spot area&invasive margin focus), e.g. for CD3, the relationship with prognostic factors [Crohn's-like reaction (p = 0.015), positive surgical margin (p = 0.019), Mismatch repair proteins deficiency (p = 0.003), advanced grade (p = 0.015)], the correlation of distinct estimates (r = 0.708), the reproducibility of research (Kappa = 0.60-0.71), and the usefulness of cut-off value (area of under ROC = 0.800 [0.683-0.917]) were best. Then, survival analysis was performed with two better methods including Model A. In univariate analysis, low TIL with Model A was associated with worse OS (CD3, p < 0.001; CD8, p = 0.023) and RFS (CD3, p < 0.001; CD8, p = 0.005). Multivariate analyses confirmed low TIL with same method as an independent worse prognostic marker for OS (CD3, Hazard ratio [HR] = 1.42 [1.10-1.85], p = 0.005) and RFS (CD3, HR = 1.46 [1.17-1.83], p = 0.001; CD8, HR = 1.32 [1.05-1.64], p = 0.032). Conclusions: Our results confirm that low TIL is an independent worse prognostic marker in stage IIA (T3N0) CC and that the use of CD3 with Model A can contribute to improving the prognostication of early CCs.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.anndiagpath.2019.05.007
dc.identifier.endpage78en_US
dc.identifier.issn1092-9134
dc.identifier.issn1532-8198
dc.identifier.pmid31146180
dc.identifier.scopus2-s2.0-85067981167
dc.identifier.scopusqualityQ2
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.1016/j.anndiagpath.2019.05.007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7720
dc.identifier.volume41en_US
dc.identifier.wosWOS:000483427400010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofAnnals Of Diagnostic Pathology
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTumour-infiltrating T lymphocyteen_US
dc.subjectColon canceren_US
dc.subjectStage IIAen_US
dc.titlePrognostic role of tumour-infiltrating T lymphocytes in stage IIA (T3N0) colon cancer: A broad methodological study in a fairly homogeneous populationen_US
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Prognostic role of tumour-infiltrating T lymphocytes in stage IIA (T3N0) colon cancer A broad methodological study in a fairly homogeneous population.pdf
Boyut:
2.7 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Diğer Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu