Is resveratrol therapeutic when used to treat allergic rhinitisinitis in rats?

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dc.contributor.authorBozdemir, Kazim
dc.contributor.authorSahin, Ethem
dc.contributor.authorAltintoprak, Niyazi
dc.contributor.authorMuluk, Nuray B.
dc.contributor.authorCengiz, Betul P.
dc.contributor.authorAcar, Mustafa
dc.contributor.authorCingi, Cemal
dc.date.accessioned2020-06-25T18:22:28Z
dc.date.available2020-06-25T18:22:28Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: Resveratrol has anti-infective, anti-inflammatory and antioxidant activities. The purpose of this study was to determine the effect of resveratrol in a rat experimental model of allergic rhinitis (AR). Methods: Wistar albino rats were divided into three groups: control (n=7), AR with no treatment (AR+NoTr, n=7) and AR with resveratrol treatment (AR+Res, n=7). For AR+Res, AR was induced and resveratrol given on days 21-28. On day 28, the total blood IgE levels were measured. Allergic symptoms (sneezing, nose-rubbing, eye lacrimation and nasal congestion) were scored on a 0-3 point scale, and histopathological changes in the nasal mucosa were evaluated. Results: Allergic symptom score of AR+NoTr was higher than the other two groups and the score of AR+Res was higher than the control group. Histopathologically, neither ciliary loss nor chondrocyte hypertrophy differed among the three groups; however, vascular congestion, inflammatory and plasma cell numbers, eosinophil and mast cell infiltration and goblet cell numbers were higher and mast cell infiltration was more prominent in AR+NoTr than in AR+Res and control. AR+Res and control did not differ significantly in any histological parameter. In AR+NoTr, nasal mucosa exhibited ciliary loss, squamous epithelial metaplasia, inflammatory cell infiltration, vascular congestion of the lamina propria and goblet cell epithelial metaplasia. In AR+Res, goblet cell metaplasia was focal or absent and infiltration of the lamina propria by inflammatory cells, eosinophils, and plasma cells was reduced relative to AR+NoTr. Conclusion: Allergic symptoms and tissue reactions were reduced by resveratrol treatment in rats with experimentally-induced AR.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpageE72en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue2en_US
dc.identifier.pmid27040862
dc.identifier.scopus2-s2.0-85010005909
dc.identifier.scopusqualityQ2
dc.identifier.startpageE63en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6753
dc.identifier.volume39en_US
dc.identifier.wosWOS:000373218500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleIs resveratrol therapeutic when used to treat allergic rhinitisinitis in rats?en_US
dc.typeArticle

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