A Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrate

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dc.contributor.authorYildirim, Engin
dc.contributor.authorDerici, Mehmet Kursat
dc.date.accessioned2020-06-25T18:34:04Z
dc.date.available2020-06-25T18:34:04Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionDerici, Mehmet Kursat/0000-0002-8260-7492
dc.description.abstractBackground: Polycystic ovary syndrome (PCOS) is associated with infertility or subfertility due to impaired ovulation. Clomiphene citrate is a first-line treatment option for the induction of ovulation in women with PCOS. The study aimed to compare markers of oxidative stress or the total oxidative status (TOS), total antioxidant status (TAS), and levels of paraoxonase-1 (PON-1) before and after day 21 of the menstrual cycle in women with PCOS treated with clomiphene citrate to induce ovulation. Material/Methods: The study included 75 women who were divided into a control group (n=25) that included healthy untreated women, untreated women with PCOS (n=24) who had spontaneous ovulation, and women with PCOS who were treated with clomiphene citrate for subfertility or infertility (n=26) (the PCOS-CC group). The study group was treated for five days with clomiphene citrate (50 mg/day). Peripheral venous blood was sampled on day 3 and day 21 of the menstrual cycle from women in all three groups, and TAS, TOS, and PON-1 levels were measured. Results: In all three groups, TAS and PON levels were significantly reduced and TOS values were significantly increased on day 21 of the menstrual cycle. Comparison of TAS, TOS, and PON-1 levels between the three study groups on day 3 and day 21 of the menstrual cycle showed no significant difference (p=0.600, p=0.223, p=0.956, respectively). Conclusions: This study showed that spontaneous ovulation occurs in association with an oxidative state in healthy women and women with PCOS, and women with PCOS following treatment with clomiphene citrate.en_US
dc.description.sponsorshipHitit UniversityHitit University [TIP19001.18.001]en_US
dc.description.sponsorshipThis study was supported by Hitit University (Grant No: TIP19001.18.001)en_US
dc.identifier.citationYildirim E, Derici MK. A Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrate. Med Sci Monit. 2019 May 26;25:3910-3917.en_US
dc.identifier.doi10.12659/MSM.914338
dc.identifier.endpage3917en_US
dc.identifier.issn1643-3750
dc.identifier.pmid31129677
dc.identifier.scopus2-s2.0-85066947050
dc.identifier.scopusqualityQ1
dc.identifier.startpage3910en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.914338
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7782
dc.identifier.volume25en_US
dc.identifier.wosWOS:000469780700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectAryldialkylphosphataseen_US
dc.subjectOxidative Stressen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.titleA Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrateen_US
dc.typeArticle

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