Differential expressions and functions of phosphodiesterase enzymes in different regions of the rat heart

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dc.contributor.authorDerici, Mehmet Kursat
dc.contributor.authorSadi, Gokhan
dc.contributor.authorCenik, Basar
dc.contributor.authorGuray, Tulin
dc.contributor.authorDemirel-Yilmaz, Emine
dc.date.accessioned2020-06-25T18:34:19Z
dc.date.available2020-06-25T18:34:19Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.descriptionDemirel-Yilmaz, Emine/0000-0002-2476-6225; Derici, Mehmet Kursat/0000-0002-8260-7492; Guray, Tulin/0000-0003-4572-1429
dc.description.abstractPhosphodiesterase enzymes (PDEs) are responsible for the adjustment of cyclic nucleotide levels. Alterations in PDE expressions in different tissues cause conflicts between functional and clinical effects of PDE inhibitors. Therefore, the aim of this study was to investigate the gene and protein expressions and the functional role of PDEs in atrium and ventricle of rat heart The expressions of PDEs were examined in cardiac intact tissues and enzymatically isolated cells. The effects of PDE1-5 inhibitors (vinpocetine, EHNA, milrinone, rolipram, sildenafil, and IBMX) on basal and isoprenaline-stimulated contractions and sinus rate were recorded in the isolated spontaneously beating right atrium and electrically stimulated left papillary muscles. The mRNA and protein levels of PDEs were significantly different in atrial and ventricular intact tissues and isolated myocytes. Atrial contractions were increased with vinpocetine while suppressed by EHNA, milrinone, rolipram, sildenafil and IBMX. Milrinone, sildenafil and IBMX increased the heart rate whereas vinpocetine caused negative chronotropy. Papillary muscle contractions have been increased only with the vinpocetine and IBMX. Both the expression and the action of PDE-1-5 show atrial and ventricular differences. Therefore, these differences should be taken into account in the experimental or therapeutic approaches of the heart.en_US
dc.description.sponsorshipAnkara University Research Foundation Ankara, TurkeyAnkara University [13B3330007]en_US
dc.description.sponsorshipThis study was supported by a research grants, 13B3330007 from the Ankara University Research Foundation Ankara, Turkey.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ejphar.2018.12.002
dc.identifier.endpage129en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.pmid30529467
dc.identifier.scopus2-s2.0-85058244018
dc.identifier.scopusqualityQ1
dc.identifier.startpage118en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2018.12.002
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7863
dc.identifier.volume844en_US
dc.identifier.wosWOS:000455010800015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhosphodiesteraseen_US
dc.subjectExpressionen_US
dc.subjectFunctionen_US
dc.subjectRight atriumen_US
dc.subjectPapillary muscleen_US
dc.titleDifferential expressions and functions of phosphodiesterase enzymes in different regions of the rat hearten_US
dc.typeArticle

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