Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats

Basit Öğe Kaydı
dc.contributor.authorOzer, Abdullah
dc.contributor.authorKilic, Yigit
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorMardin, Baris
dc.contributor.authorAlkan, Metin
dc.contributor.authorOktar, Levent
dc.date.accessioned2020-06-25T18:29:36Z
dc.date.available2020-06-25T18:29:36Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Ischemia-reperfusion injury is a chain of events put in place by tissue ischemia. Reperfusion following the damage of cell causes an active inflammatory response. In our research we tried to evaluate the protective effect of Levosimendan and Nigella Sativa on myocardial ischemia-reperfusion injury in rats. Methods: We included twenty-four Wistar albino rats in our research. The rats were randomly divided into four experimental groups. The coronary arteries of rats in Group C (control group) were not occluded or reperfused. Left anterior descending coronary artery was ligated for 30 min to perform myocardial IR and then reperfused for 2 h in the IR (IR), IR-Levosimendan (24 mu g/kg) (IRL) and IR-Nigella Sativa (0.2 mL/kg) (IRNS) group. Results: Inflammation findings were significantly higher in the IR group compared with the C, IR-NS, and IR-L groups (p=0.001, p=0.019, p=0.019, respectively). Compared with the C, IR-NS, and IR-L groups, the microscopic myocardial disorganization was significantly higher among the IR group (p<0.0001, p=0.007, p=0.001, respectively). The light microscopic myocardial tissue interstitial fibrosis levels were significantly higher in the IR group than in the C, IR-NS, and IR-L groups (p<0.0001, p=0.044, p=0.003, respectively). Conclusion: Levosimendan and NS administration at the beginning of myocardial ischemia can provide varying degrees of protection against negative effects of variations in light microscopic inflammation findings, myocardial disorganization degrees and myocardial tissue interstitial fibrosis levels.en_US
dc.identifier.citationÖzer A., Kılıç Y., Sezen Ş. C., Küçük A., Mardin B., Alkan M., Arslan M., Ünal Y., Oktar G. L. (2018). Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats. Gazi Medical Journal, 29(3), 219 - 222.en_US
dc.identifier.doi10.12996/gmj.2018.60
dc.identifier.endpage222en_US
dc.identifier.issn2147-2092
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85049906682
dc.identifier.scopusqualityQ4
dc.identifier.startpage219en_US
dc.identifier.trdizinid294936
dc.identifier.urihttps://doi.org/10.12996/gmj.2018.60
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7392
dc.identifier.volume29en_US
dc.identifier.wosWOS:000437529600014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGazi Univ, Fac Meden_US
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia reperfusionen_US
dc.subjectLevosimendanen_US
dc.subjectNigella Sativaen_US
dc.subjecthearten_US
dc.titleAssessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Ratsen_US
dc.typeArticle

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