Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats

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dc.authoridgomec, muhammed/0000-0002-9127-3201
dc.authoridUcar, Cahit/0000-0002-3386-0301
dc.authoridSahin, Yasar/0000-0001-5936-4210
dc.authoridOzden, Huseyin/0000-0002-2786-3805
dc.authoridYILDIZ, Ahmet/0000-0002-6889-4528
dc.contributor.authorozden, Huseyin
dc.contributor.authorSahin, Yasar
dc.contributor.authorKilitci, Asuman
dc.contributor.authorKaraca, Gokhan
dc.contributor.authorGomec, Muhammed
dc.contributor.authorYildiz, Ahmet
dc.contributor.authorUcar, Cahit
dc.date.accessioned2025-01-21T16:36:51Z
dc.date.available2025-01-21T16:36:51Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractPurpose: The etiology and pathogenesis of distal colitis (DC) are poorly understood. Activation of intestinal inflammatory response may lead to intestinal tissue necrosis. Antioxidant and anti-inflammatory agents are among the treatment options. Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA) induced colitis in rats. Methods: Twenty-four rats were randomly grouped as colitis, mesalazine, G. lucidum, and combined (G. lucidum + mesalazine) groups. DC was induced by intrarectal administration of AA. Statistical comparisons were done by using parameters including colonic tissue IL-1, IL-6, TNF-alpha, and CRP levels. Histopathologic changes of the samples of colonic tissue were scored as mucosal damage score and inflammatory score. A P-value of <0.05 was considered significant. Results: Intrarectal administration of AA leads to increased interleukin and CRP levels. High mucosal damage and inflammatory scores were noted in colitis group animals. Single mesalazine or G. lucidum treatment produced considerably decreased tissue interleukin and CRP levels. The lowest tissue interleukin and CRP levels were noted in the combined treatment group of animals. Mucosal damage and inflammatory scores were found to be significantly low in this group of animals. Conclusion: The intrarectal administration of AA results in an activation of intestinal inflammation and severe mucosal damage in colonic tissue. Single use of mesalazine and G. lucidum treatment decreases the severity of intestinal inflammatory response and mucosal damage. The healing effects of the combined treatment of mesalazine and G. lucidum seem to be more effective than that of separate use in the treatment of DC.
dc.identifier.doi10.4174/astr.2022.102.1.29
dc.identifier.endpage35
dc.identifier.issn2288-6575
dc.identifier.issn2288-6796
dc.identifier.issue1
dc.identifier.pmid35071117
dc.identifier.scopus2-s2.0-85123521428
dc.identifier.scopusqualityQ2
dc.identifier.startpage29
dc.identifier.urihttps://doi.org/10.4174/astr.2022.102.1.29
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24395
dc.identifier.volume102
dc.identifier.wosWOS:000744053900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Surgical Society
dc.relation.ispartofAnnals of Surgical Treatment and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAcetic acid; Distal colitis; Ganoderma lucidum; Mesalazine
dc.titleComparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats
dc.typeArticle

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