Direct Effect of Caffeine on Diaphragmatic Muscles in Preterm Babies Through Ultrasonographic Examination

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dc.contributor.authorKayki, Gozdem
dc.contributor.authorCelik, Hasan Tolga
dc.contributor.authorAyaz, Ercan
dc.contributor.authorTandircioglu, Umit Ayse
dc.contributor.authorOguz, Berna
dc.contributor.authorYigit, Sule
dc.contributor.authorYurdakok, Murat
dc.date.accessioned2025-01-21T16:37:45Z
dc.date.available2025-01-21T16:37:45Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Caffeine is frequently used for the treatment of apnea in preterm babies. Its mechanism of action includes not only antagonism of adenosine receptors on central nervous system but also an increase in electrical activity of the diaphragm. Caffeine's direct effect on diaphragm was investigated via electromyography, but ultrasound has not been used to show visible changes in muscles after the treatment before. Therefore, we aimed to assess the effect of caffeine on diaphragmatic function through ultrasonographic examination. Materials and Methods: It was a prospective observational study. Fifty-six participants receiving nasal continuous positive airway pressure with less than or equal to 32 weeks' gestational age born were enrolled. Diaphragmatic thickness, amplitude of excursion, and velocity of movement were measured before and within 5 minutes after caffeine loading dose and compared to each other. The protocol was registered with ClinicalTrials.gov Identifier NCT04483492. Results: Diaphragmatic thicknesses and diaphragmatic velocity of movement did not differ after the treatment. However, amplitude of excursion of the diaphragm was found significantly higher after caffeine loading dose (8.7 mm, 10mm, respectively, P < .05). Conclusion: Diaphragm excursion increased after caffeine treatment in preterm babies, and this finding was potentially supported the direct effect of the caffeine on diaphragm. Another important finding of this study is that it reinforces the utility of ultrasonography in assessing diaphragmatic function in preterm infants.
dc.identifier.doi10.5152/TurkArchPediatr.2024.23290
dc.identifier.issn2757-6256
dc.identifier.issue3
dc.identifier.pmid39140727
dc.identifier.scopus2-s2.0-85193233692
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.5152/TurkArchPediatr.2024.23290
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24524
dc.identifier.volume59
dc.identifier.wosWOS:001344674000008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Archives of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCaffeine; excursion; diaphragm thickness; diaphragmatic velocity; preterm infants
dc.titleDirect Effect of Caffeine on Diaphragmatic Muscles in Preterm Babies Through Ultrasonographic Examination
dc.typeArticle

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