Serum leptin levels and their relationship to tumor necrosis factor-? and interleukin-6 in neonatal sepsis

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dc.contributor.authorKoç, Esin
dc.contributor.authorÜstündağ, Gonca
dc.contributor.authorAliefendioğlu, Didem
dc.contributor.authorErgenekon, Ebru
dc.contributor.authorBideci, A.
dc.contributor.authorAtalay, Yusuf
dc.date.accessioned2020-06-25T15:13:18Z
dc.date.available2020-06-25T15:13:18Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractCirculating leptin concentrations are raised in animal models of inflammation and sepsis and leptin production is also increased in rodents by administration of endotoxin or cytokines. The purpose of this study was to investigate the effect of sepsis on serum leptin concentration and whether circulating leptin was related to tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6) release in newborn infants. Plasma leptin, TNF-? and IL-6 were measured in 20 neonates with culture-proven sepsis as soon as sepsis was diagnosed and after recovery and in 15 healthy control infants. There was no significant difference in plasma leptin levels between septic and control infants (p>0.05); there was also no difference in plasma leptin levels in septic neonates before and after therapy (p >0.05). No relationship between leptin and TNF-? (r = 0.16, p >0.05) or I1-6 (r = 0.12, p >0.05) was identified. These findings suggest that a major role of leptin in acute neonatal sepsis appears unlikely.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage1287en_US
dc.identifier.issn0334018X
dc.identifier.issue9en_US
dc.identifier.pmid14714752
dc.identifier.scopus2-s2.0-0348143310
dc.identifier.scopusqualityQ2
dc.identifier.startpage1283en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1720
dc.identifier.volume16en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofJournal of Pediatric Endocrinology and Metabolism
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterleukin-6en_US
dc.subjectNewbornen_US
dc.subjectSepsis leptinen_US
dc.subjectTumor necrosis factor-?en_US
dc.titleSerum leptin levels and their relationship to tumor necrosis factor-? and interleukin-6 in neonatal sepsisen_US
dc.typeArticle

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