Pectin-conjugated magnetic graphene oxide nanohybrid as a novel drug carrier for paclitaxel delivery

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dc.contributor.authorHussien, Nizamudin Awel
dc.contributor.authorIsiklan, Nuran
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2020-06-25T18:29:48Z
dc.date.available2020-06-25T18:29:48Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractRecent studies have shown that graphene oxide (GO) drug carrier functionalized with biocompatible natural polymers lead to higher loading efficacy and better stability with diminished cellular toxicity. Pectin (PEC) is one of the polysaccharide natural polymers, which has the potential to be used for drug delivery. In this work, we have successfully developed a novel PEC-conjugated magnetic GO nanocarrier for effective delivery of paclitaxel. The structure, surface morphology and thermal stability of the nanohybrid were investigated using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM) and zeta-sizer. Moreover, drug loading and release performance were studied by UV-vis absorption spectra. The cytotoxicity test was also performed by MTT test using L-929 fibroblast normal cell and MCF-7 cancer lines. The prepared nanocarrier showed an improved stability with enhanced drug loading capacity. Additionally, pH-responsive release analysis of the nanohybrid illustrated higher drug release at endosomal pH of cancer cell than that of normal physiological environment. Besides, cytotoxicity test demonstrated the synthesized nanohybrid is biocompatible, having very high relative cell viability. Bearing in mind these findings, the designed multifunctional nanohybrid drug carrier will be a good candidate for cancer drug delivery.en_US
dc.description.sponsorshipKirikkale University, under BAP project [2017/055]en_US
dc.description.sponsorshipThe authors thankfully acknowledge the fund support given by Kirikkale University, under BAP project reference number 2017/055, 2017.en_US
dc.identifier.citationNizamudin Awel Hussien, Nuran Işıklan & Mustafa Türk (2018) Pectinconjugated magnetic graphene oxide nanohybrid as a novel drug carrier for paclitaxel delivery, Artificial Cells, Nanomedicine, and Biotechnology, 46:sup1, 264-273.en_US
dc.identifier.doi10.1080/21691401.2017.1421211
dc.identifier.endpageS273en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.pmid29298530
dc.identifier.scopus2-s2.0-85040981300
dc.identifier.scopusqualityQ1
dc.identifier.startpageS264en_US
dc.identifier.urihttps://doi.org/10.1080/21691401.2017.1421211
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7465
dc.identifier.volume46en_US
dc.identifier.wosWOS:000457049400024
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine And Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNanocarrieren_US
dc.subjectgraphene oxideen_US
dc.subjectpolymeren_US
dc.subjectpectinen_US
dc.subjectbiocompatibilityen_US
dc.subjectdrug deliveryen_US
dc.titlePectin-conjugated magnetic graphene oxide nanohybrid as a novel drug carrier for paclitaxel deliveryen_US
dc.typeArticle

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