Adenosine deaminase and 5 '-nucleotidase activities in saliva from patients with oral and laryngeal cancer

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dc.contributor.authorSaracoğlu, Umut
dc.contributor.authorGüven, Orhan
dc.contributor.authorDurak, İlker
dc.date.accessioned2020-06-25T17:40:27Z
dc.date.available2020-06-25T17:40:27Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The aim of this study was to evaluate saliva's activities of adenosine deaminase (ADA) and 5'-nucleotidase (5'-NT) enzymes and their utility as diagnostic and therapeutic markers in oral and laryngeal cancer. Materials and Methods: Pre- and post-operative saliva's activities of ADA and 5'-NT enzymes were measured in patients with squamous cell oral (n=10) and laryngeal cancer (n=17) and compared with control saliva samples (n=19). Results: The ADA was found to be lower in saliva of the patients with oral cancer compared with the laryngeal cancer and controls. However, no significant differences were found between pre- and post-operative values for both enzymes in the patient groups. We also could not find statistically significant differences between saliva's activities of 5'-NT in patients and control subjects. Conclusions: Low activity of ADA observed in saliva of the patients with oral cancer has been suggested as a compensatory mechanism against rapid purine and DNA metabolism in cancer cells. The current study does not support the hypothesis that saliva's activities of these enzymes may be used as additional diagnostic and prognostic cancer markers.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1601-0825.2005.01131.x
dc.identifier.endpage325en_US
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue5en_US
dc.identifier.pmid16120121
dc.identifier.scopus2-s2.0-25144432958
dc.identifier.scopusqualityQ1
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.1111/j.1601-0825.2005.01131.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3442
dc.identifier.volume11en_US
dc.identifier.wosWOS:000231909300011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofOral Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadenosine deaminaseen_US
dc.subject5 '-nucleotidaseen_US
dc.subjectoral and laryngeal canceren_US
dc.subjectsalivaen_US
dc.titleAdenosine deaminase and 5 '-nucleotidase activities in saliva from patients with oral and laryngeal canceren_US
dc.typeArticle

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