Synthesis of biocompatible Ti-6Al-4V composite reinforced with ZrO2 and bioceramic produced by powder metallurgy: Morphological, structural, and biocompatibility analysis

Basit Öğe Kaydı
dc.authoridPUL, MUHARREM/0000-0002-0629-3516
dc.authoridErdem, Umit/0000-0002-0480-8176
dc.contributor.authorPul, Muharrem
dc.contributor.authorErdem, Umit
dc.contributor.authorBozer, Busra Moran
dc.contributor.authorSimsek, Tuncay
dc.contributor.authorYilmazel, Rustem
dc.contributor.authorErten, Mustafa Yasin
dc.date.accessioned2025-01-21T16:44:49Z
dc.date.available2025-01-21T16:44:49Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this experimental study, the initial phase involved preparing composite structures with various mix ratios using the Ti-6Al-4V alloy, widely used in clinical applications, in conjunction with ZrO2 and hydroxyapatite (HA) synthesized via the precipitation method, employing powder metallurgy techniques. Subsequently, the microstructures of the resultant hybrid composite materials were imaged, and x-ray diffraction (XRD) phase analyses were conducted. In the final phase of the experimental work, tests were performed to determine the biocompatibility properties of the hybrid composites. For this purpose, cytotoxicity and genotoxicity assays were carried out. The tests and examinations revealed that structures compatible both morphologically and elementally were obtained with no phase transformations that could disrupt the structure. The incorporation of ZrO2 into the Ti-6Al-4V alloy was observed to enhance cell viability values. The value of 98.25 +/- 0.42 obtained by adding 20% ZrO2 gave the highest cell viability result. The addition of HA into the hybrid structures further increased the cell viability values by approximately 10%. All viability values for both HA-added and HA-free groups were obtained above the 70% viability level defined in the standard. According to the genotoxicity test results, the highest cytokinesis-block proliferation index values were obtained as 1.666 and 0.620 in structures containing 20% ZrO2 and 10% ZrO2 + 10% HA, respectively. Remarkably, all fabricated composite and hybrid composite materials surpassed established biocompatibility standards and exhibited nontoxic and nongenotoxic properties. This comprehensive study contributes vital insights for future biomechanical and other in vitro and in vivo experiments, as it meticulously addresses fundamental characterization parameters crucial for medical device development.
dc.description.sponsorshipKimath;rimath;kkale University Scientific Research Projects Unit [2023/024]
dc.description.sponsorshipThe authors would like to express their gratitude to K & imath;r & imath;kkale University Scientific Research Projects Unit for its financial support in spectral analysis. Project number: 2023/024.
dc.identifier.doi10.1002/jemt.24646
dc.identifier.endpage2744
dc.identifier.issn1059-910X
dc.identifier.issn1097-0029
dc.identifier.issue11
dc.identifier.pmid38988128
dc.identifier.scopus2-s2.0-85198110964
dc.identifier.scopusqualityQ1
dc.identifier.startpage2728
dc.identifier.urihttps://doi.org/10.1002/jemt.24646
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25516
dc.identifier.volume87
dc.identifier.wosWOS:001269982900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectbiocompatibility; cytotoxicity; hydroxyapatite; Ti-6Al-4V; ZrO2
dc.titleSynthesis of biocompatible Ti-6Al-4V composite reinforced with ZrO2 and bioceramic produced by powder metallurgy: Morphological, structural, and biocompatibility analysis
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu