Mechanisms of Allergen-Specific Immunotherapy and Novel Ways for Vaccine Development

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dc.contributor.authorJutel, Marek
dc.contributor.authorVan de Veen, Willem
dc.contributor.authorAgache, Ioana
dc.contributor.authorAzkur, Kursat A.
dc.contributor.authorAkdis, Muebeccel
dc.contributor.authorAkdis, Cezmi A.
dc.date.accessioned2020-06-25T18:06:55Z
dc.date.available2020-06-25T18:06:55Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAllergen-specific immunotherapy (SIT) is the only available curative treatment of allergic diseases. Recent evidence provided a plausible explanation to its multiple mechanisms inducing both rapid desensitization and long-term allergen-specific immune tolerance, and suppression of allergic inflammation in the affected tissues. During SIT, peripheral tolerance is induced by the generation of allergen-specific regulatory T cells, which suppress proliferative and cytokine responses against the allergen of interest. Regulatory T cells are characterized by IL-10 and TGF-beta secretion and expression of important cell surface suppressive molecules such as cytotoxic T lymphocyte antigen-4 and programmed death-1 that directly or indirectly influence effector cells of allergic inflammation, such as mast cells, basophils and eosinophils. Regulatory T cells and particularly IL-10 also have an influence on B cells, suppressing IgE production and inducing the production of blocking type IgG4 antibodies. In addition, development of allergen-specific B regulatory cells that produce IL-10 and develop into IgG4 producing plasma cells represent essential players in peripheral tolerance. These findings together with the new biotechnological approaches create a platform for development of the advanced vaccines. Moreover, reliable biomarkers could be selected and validated with the intention to select the patients who will benefit most from this immune-modifying treatment. Thus, allergen-SIT could provide a complete cure for a larger number of allergic patients and novel preventive approaches need to be elaborated.en_US
dc.description.sponsorshipSwiss National Science FoundationSwiss National Science Foundation (SNSF) [320030-132899, 32-125249]; Christine Kuhne-Center for Allergy Research and Education; Davos (CK-CARE); MeDALL: Mechanisms of the Development of Allergy (European 7th frame work project) [261357]; Polish National Science Centre [2011/01/B/NZ6/01872, 2012/04/M/NZ6/00355, 2012/04/A/NZ6/00407]en_US
dc.description.sponsorshipThe author's laboratories are supported by the Swiss National Science Foundation (grant 320030-132899, 32-125249), Christine Kuhne-Center for Allergy Research and Education, Davos (CK-CARE), MeDALL: Mechanisms of the Development of Allergy (European 7th frame work project No: 261357), and Polish National Science Centre (grants No. 2011/01/B/NZ6/01872, 2012/04/M/NZ6/00355 and 2012/04/A/NZ6/00407).en_US
dc.identifier.citationJutel, M., Van de Veen, W., Agache, I., Azkur, K. A., Akdis, M., & Akdis, C. A. (2013). Mechanisms of allergen-specific immunotherapy and novel ways for vaccine development. Allergology international : official journal of the Japanese Society of Allergology, 62(4), 425–433.en_US
dc.identifier.doi10.2332/allergolint.13-RAI-0608
dc.identifier.endpage433en_US
dc.identifier.issn1323-8930
dc.identifier.issn1440-1592
dc.identifier.issue4en_US
dc.identifier.pmid24153333
dc.identifier.scopus2-s2.0-84890029081
dc.identifier.scopusqualityQ1
dc.identifier.startpage425en_US
dc.identifier.urihttps://doi.org/10.2332/allergolint.13-RAI-0608
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5409
dc.identifier.volume62en_US
dc.identifier.wosWOS:000328179600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJapanese Society Allergologyen_US
dc.relation.ispartofAllergology International
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectallergy vaccinesen_US
dc.subjectB regulatory cellsen_US
dc.subjectdesensitizationen_US
dc.subjectimmune toleranceen_US
dc.subjectT regulatory cellsen_US
dc.titleMechanisms of Allergen-Specific Immunotherapy and Novel Ways for Vaccine Developmenten_US
dc.typeReview Article

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