Assessment of free-radical scavenging activity of Gypsophila pilulifera: assay-guided isolation of verbascoside as the main active component

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dc.contributor.authorChima, Navdeep K.
dc.contributor.authorNahar, Lutfun
dc.contributor.authorMajinda, Runner R. T.
dc.contributor.authorÇelik, Sezin
dc.contributor.authorSarker, Satyajit D.
dc.date.accessioned2020-06-25T18:12:33Z
dc.date.available2020-06-25T18:12:33Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractGypsophila pilulifera, Boiss & Heldr, Caryophyllaceae, is a perennial medicinal herb that grows in the-southwestern region of Turkey. Except for only one report on the isolation-of cytotoxic. saponins from the underground parts of G. pilulifera, there are no published thorough phytochemical or bioactivity studies on this specie. In the present study; the free-radical Scavenging activity of extracts and fractions of the-stems of G. pilulifera was evaluated, using a. slightly modified and more-precise-version of the 2,2-diphenyl-1-picrylhydrazyl (DRPH) assay, :reported here for the first time. The DPPH assay-guided HPLC-PDA-purification of the active solid-phase extraction fraction (50% methanol in water) of the methanolic-extract exhibited verbascoside as the main free-radical Scavenger present in this species. The structure of this active compound was resolved by spectroscopy, and the free-radical scavenging potential of verbascoside was determined. (C) 2014 Sociedade Brasileira. de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved..en_US
dc.identifier.citationChima, N.K., Nahar, L., Majinda, R.R., Çelik, S., & Sarker, S.D. (2014). Assessment of free-radical scavenging activity of Gypsophila pilulifera: assay-guided isolation of verbascoside as the main active component. Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy, 24(1), 38-43.en_US
dc.identifier.doi10.1590/0102-695X20142413391
dc.identifier.endpage43en_US
dc.identifier.issn0102-695X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84901275857
dc.identifier.scopusqualityQ2
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.1590/0102-695X20142413391
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5965
dc.identifier.volume24en_US
dc.identifier.wosWOS:000336187800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSoc Brasileira Farmacognosiaen_US
dc.relation.ispartofRevista Brasileira De Farmacognosia-Brazilian Journal Of Pharmacognosy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGypsophila piluliferaen_US
dc.subjectFree-radical scavengeren_US
dc.subjectSolid-phase extractionen_US
dc.subjectHigh-performance liquid chromatography (HPLC)en_US
dc.subjectPhenylethanoiden_US
dc.subjectVerbascosideen_US
dc.titleAssessment of free-radical scavenging activity of Gypsophila pilulifera: assay-guided isolation of verbascoside as the main active componenten_US
dc.typeArticle

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