Monitoring Genetic Diversity of Influenza A(H1N1)pdm09 Virus Circulating during the Post-Pandemic Period in Turkey

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dc.contributor.authorGuldemir, Dilek
dc.contributor.authorKalaycioglu, Atila T.
dc.contributor.authorAltas, A. Basak
dc.contributor.authorKorukluoglu, Gulay
dc.contributor.authorDurmaz, Riza
dc.date.accessioned2020-06-25T18:07:09Z
dc.date.available2020-06-25T18:07:09Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aimes of the present study were to monitor genetic alterations in the hemagglutin (HA) gene and oseltamivir resistance-related alterations in the neuraminidase (NA) gene of influenza A(H1N1)pdm09 viral isolates detected during the post-pandemic period in Turkey. A total of 2601 clinical specimens obtained from suspected cases of influenza A(H1N1)pdm09 viral infections were analyzed by real-time reverse transcription polymerase chain reaction. Viral RNA was detected in 233 (9%) clinical specimens. Sequence analysis of the HA gene in 16 random isolates showed >98.7% homology among each other and with the A/California/07/2009 vaccine strain. These 16 isolates had common (75%-100%) amino acid substitiutions at positions P83S, D97N, S203T, R205K, I216V, V249L, I321V, and E374K in the HA gene. In addition, two additional rare mutations were also observed at positions S162N (addition of a glycosylation site, 6.25%) and A186T (receptor binding region, 6.25%). On the basis of amino acid substitutions in the HA1 domain, majority of the Turkish isolates were classified in the genetic group v and others in the genetic groups ii, iii, and vi. In the present study, we observed an increase in the variety and ratio of mutations detected in the HA1. and HA2 domains of the HA gene; however, these alterations have not yet resulted in vaccine escape mutants in Turkey. In addition, analysis of the NA regions of the isolates revealed that oseltamivir resistance was not an issue in Turkey.en_US
dc.identifier.citationGuldemir, D., Kalaycioglu, A. T., Altas, A. B., Korukluoglu, G., & Durmaz, R. (2013). Monitoring genetic diversity of influenza A(H1N1)pdm09 virus circulating during the post-pandemic period in Turkey. Japanese journal of infectious diseases, 66(4), 299–305.en_US
dc.identifier.doi10.7883/yoken.66.299
dc.identifier.endpage305en_US
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue4en_US
dc.identifier.pmid23883840
dc.identifier.scopus2-s2.0-84880676841
dc.identifier.scopusqualityQ2
dc.identifier.startpage299en_US
dc.identifier.urihttps://doi.org/10.7883/yoken.66.299
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5495
dc.identifier.volume66en_US
dc.identifier.wosWOS:000322850800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNatl Inst Infectious Diseasesen_US
dc.relation.ispartofJapanese Journal Of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleMonitoring Genetic Diversity of Influenza A(H1N1)pdm09 Virus Circulating during the Post-Pandemic Period in Turkeyen_US
dc.typeArticle

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