Pitfalls in the management of Cushing's disease

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dc.contributor.authorBademci, Gülşah
dc.date.accessioned2020-06-25T17:43:49Z
dc.date.available2020-06-25T17:43:49Z
dc.date.issued2007
dc.description.abstractCushing's disease is caused by functional corticotroph adenomas of the pituitary gland, most commonly noninvasive microadenomas. Transsphenoidal microsurgery is an effective means of control for patients with adrenocorticotrophic hormone-producing microadenomas. However, a wide variation of clinical outcomes and recurrence rates has been reported. The major causes of surgical failure in the treatment of Cushing's disease lies in inadequate preoperative evaluation, unsuccessful identification of the adenoma and inexperience of the surgeon. Furthermore, appropriate use of combination therapy, including surgery, radiotherapy, radiosurgery and adrenalectomy can improve the outcome. For optimal results in this rare disease, endocrinological, radiological and surgical procedures should be co-ordinated in a specialized center. In this review, factors affecting preoperative evaluation, surgical success and outcome are outlined in the light of current knowledge. (C) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jocn.2006.10.004
dc.identifier.endpage408en_US
dc.identifier.issn0967-5868
dc.identifier.issue5en_US
dc.identifier.pmid17386367
dc.identifier.scopus2-s2.0-33947409878
dc.identifier.scopusqualityQ1
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org10.1016/j.jocn.2006.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3913
dc.identifier.volume14en_US
dc.identifier.wosWOS:000246346900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal Of Clinical Neuroscience
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCushing's diseaseen_US
dc.subjecttranssphenoidal surgeryen_US
dc.subjectradiosurgeryen_US
dc.subjectmanagementen_US
dc.subjectoutcomeen_US
dc.titlePitfalls in the management of Cushing's diseaseen_US
dc.typeReview Article

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