The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C-reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo-controlled clinical trial

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dc.contributor.authorKeceli, H. Gencay
dc.contributor.authorErcan, Nuray
dc.contributor.authorKarsiyaka Hendek, Meltem
dc.contributor.authorKisa, Ucler
dc.contributor.authorMesut, Burcu
dc.contributor.authorOlgun, Ebru
dc.date.accessioned2021-01-14T18:10:40Z
dc.date.available2021-01-14T18:10:40Z
dc.date.issued2020
dc.departmentKKÜ
dc.description.abstractAim To evaluate clinical and biochemical effects of adjunctive systemic folic acid (FA) intake with scaling and root planing (SRP) in periodontitis treatment. Materials and methods Sixty periodontitis subjects (30 per group) were randomly assigned into study groups and treated with either SRP + placebo (SRP + P) or SRP + folic acid (SRP + F). In addition to clinical parameters (plaque index [PI], gingival index [GI], probing pocket depth [PPD], clinical attachment level [CAL] and gingival recession [GR]), gingival crevicular fluid (GCF) samples were obtained at baseline and post-treatment (PT) periods (one (PT-1), three (PT-3) and six (PT-6) months) for C-reactive protein (CRP) and homocysteine (Hcy) evaluation. Results Significant time-dependent reduction was detected at all clinical parameters for both groups (p < .001). Compared to SRP + P, CAL was lower in SRP + F at PT-1 (p = .004) and PT-3 (p = .035), whereas GR was lower at only PT-1 (p = .015). GCF volume and CRP did not show inter-group differences, whereas Hcy was higher in SRP + F at PT-3 (p = .044) and PT-6 (p = .041). GCF volume and Hcy showed reduction after treatment in both groups (p < .001). Conclusion Both modalities exhibited clinical improvement and change in biochemical parameters. Adjunctive systemic FA intake may be recommended adjunctive to periodontitis treatment to reveal better outcomes. However, its impact mechanisms should be further enlightened.en_US
dc.description.sponsorshipKirikkale University Scientific Research Projects Coordination UnitKirikkale University [2012/102] Funding Source: Medlineen_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1111/jcpe.13276
dc.identifier.endpage613en_US
dc.identifier.issn0303-6979
dc.identifier.issn1600-051X
dc.identifier.issue5en_US
dc.identifier.pmid32109317
dc.identifier.scopus2-s2.0-85081934877
dc.identifier.scopusqualityQ1
dc.identifier.startpage602en_US
dc.identifier.urihttps://doi.org/10.1111/jcpe.13276
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12723
dc.identifier.volume47en_US
dc.identifier.wosWOS:000530064700007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF CLINICAL PERIODONTOLOGY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-reactive proteinen_US
dc.subjectfolic aciden_US
dc.subjectgingival crevicular fluiden_US
dc.subjecthomocysteineen_US
dc.subjectperiodontal treatmenten_US
dc.subjectperiodontitisen_US
dc.titleThe effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C-reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo-controlled clinical trialen_US
dc.typeArticle

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