Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats

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dc.contributor.authorKahveci, Ramazan
dc.contributor.authorGokce, Emre Cemal
dc.contributor.authorGurer, Bora
dc.contributor.authorGokce, Aysun
dc.contributor.authorKisa, Ucler
dc.contributor.authorCemil, Duran Berker
dc.contributor.authorErdogan, Bulent
dc.date.accessioned2020-06-25T18:08:04Z
dc.date.available2020-06-25T18:08:04Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Sargon, Mustafa Fevzi/0000-0001-6360-6008; Gurer, Bora/0000-0003-1500-6184
dc.description.abstractRosuvastatin, which is a potent stain, has never been studied in traumatic spinal cord injury. The aim of this study was to investigate whether rosuvastatin treatment could protect the spinal cord after experimental spinal cord injury. Rats were randomized into the following five groups of eight animals each: control, sham, trauma, rosuvastatin, and methylprednisolone. In the control group, no surgical intervention was performed. In the sham group, only laminectomy was performed. In all the other groups, the spinal cord trauma model was created by the occlusion of the spinal cord with an aneurysm clip. In the spinal cord tissue, caspase-3 activity, tumor necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, nitric oxide levels, and superoxide dismutase levels were analyzed. Histopathological and ultrastructural evaluations were also performed. Neurological evaluation was performed using the Basso, Beattie, and Bresnahan locomotor scale and the inclined plane test After traumatic spinal cord injury, increases in caspase-3 activity, tumor necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, and nitric oxide levels were detected. In contrast, the superoxide dismutase levels were decreased. After the administration of rosuvastatin, decreases were observed in the tissue caspase-3 activity, tumor necrosis factor-alpha levels, myeloperoxidase activity, malondialdehyde levels, and nitric oxide levels. In contrast, tissue superoxide dismutase levels were increased. Furthermore, rosuvastatin treatment showed improved results concerning the histopathological scores, the ultrastructural score and the functional tests. Biochemical, histopathological, ultrastructural analysis and functional tests revealed that rosuvastatin exhibits meaningful neuroprotective effects against spinal cord injury. (C) 2014 Elsevier B.V. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ejphar.2014.07.042
dc.identifier.endpage54en_US
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.pmid25084223
dc.identifier.scopus2-s2.0-84906561646
dc.identifier.scopusqualityQ1
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2014.07.042
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5719
dc.identifier.volume741en_US
dc.identifier.wosWOS:000343140600006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethylprednisoloneen_US
dc.subjectNeuroprotectionen_US
dc.subjectRaten_US
dc.subjectRosuvastatinen_US
dc.subjectSpinal cord injuryen_US
dc.subjectTraumaen_US
dc.titleNeuroprotective effects of rosuvastatin against traumatic spinal cord injury in ratsen_US
dc.typeArticle

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