Glucose intolerance, insulin resistance and cardiovascular risk factors in first degree relatives of women with polycystic ovary syndrome

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dc.contributor.authorYılmaz, Murat
dc.contributor.authorBukan, Neslihan
dc.contributor.authorErsoy, Reyhan
dc.contributor.authorKarakoç, Ayhan
dc.contributor.authorYetkin, İlhan
dc.contributor.authorAyvaz, Göksun
dc.contributor.authorArslan, Metin
dc.date.accessioned2020-06-25T17:40:26Z
dc.date.available2020-06-25T17:40:26Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBACKGROUND: The aim of the present study was to evaluate insulin resistance (IR), glucose tolerance status and cardiovascular risk factors in first degree relatives of patients with polycystic ovary syndrome (PCOS). METHODS: A total of 120 family members [Mothers(PCOS) (n=40), Fathers(PCOS) (n=38), Sisters(PCOS) (n=25) and Brothers(PCOS) (n=17)] of 55 patients with PCOS and 75 unrelated healthy control subjects without a family history of diabetes or PCOS (four age- and weight-matched subgroups, i.e. Control(Mothers), Control(Fathers), Control(Sisters) and Control(Brothers)) were studied. IR was assessed by homeostatic model assessment (HOMA IR), log HOMA, insulin sensivity index (ISI), the quantitative insulin sensitivity check index (QUICKI) and area under the curve for insulin during the oral glucose tolerance test (AUCI, AUCG) in with normal glucose tolerance (NGT) subjects and controls. Serum adiponectin, resistin, homocysteine and lipid levels were measured. RESULTS: The prevalence of any degree of glucose intolerance was 40% in Mothers(PCOS) and 52% in Fathers(PCOS). In total, six (15%) glucose tolerance disorders were identified in the Control(Mothers) and Control(Fathers) in first degree relatives of control subjects. The first degree relatives of PCOS patients had significantly higher serum fasting insulin, HOMA-IR, Log HOMA and AUCI levels in all subgroups than the control subjects. The control subjects had significantly elevated QUCKI, ISI levels and serum adiponectin levels compared to the first degree relatives of PCOS subjects in all subgroups. The serum Hcy and resistin levels increased significantly in both Fathers(PCOS) and Mothers(PCOS) groups but not Brothers(PCOS) and Sister(PCOS). CONCLUSION: The results of the present study support the finding that the first degree relatives of PCOS patients carry an increased risk of cardiovascular disease, as do PCOS patients.en_US
dc.identifier.citationYilmaz, M., Bukan, N., Ersoy, R., Karakoç, A., Yetkin, I., Ayvaz, G., Cakir, N., & Arslan, M. (2005). Glucose intolerance, insulin resistance and cardiovascular risk factors in first degree relatives of women with polycystic ovary syndrome. Human reproduction (Oxford, England), 20(9), 2414–2420. https://doi.org/10.1093/humrep/dei070en_US
dc.identifier.doi10.1093/humrep/dei070
dc.identifier.endpage2420en_US
dc.identifier.issn0268-1161
dc.identifier.issn1460-2350
dc.identifier.issue9en_US
dc.identifier.pmid15890734
dc.identifier.scopus2-s2.0-24044528561
dc.identifier.scopusqualityQ1
dc.identifier.startpage2414en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/dei070
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3436
dc.identifier.volume20en_US
dc.identifier.wosWOS:000231362800008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproduction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadiponectinen_US
dc.subjectfamilyen_US
dc.subjecthomocysteineen_US
dc.subjectinsulin resistanceen_US
dc.subjectPCOSen_US
dc.titleGlucose intolerance, insulin resistance and cardiovascular risk factors in first degree relatives of women with polycystic ovary syndromeen_US
dc.typeArticle

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