Effect of phototherapy on gastrointestinal smooth muscle activity and oxidative stress

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dc.contributor.authorSoyer, Tutku
dc.contributor.authorAliefendioglu, Didem
dc.contributor.authorAktuna, Zuhal
dc.contributor.authorCaglayan, Osman
dc.contributor.authorAydos, Tolga Resat
dc.contributor.authorCakmak, Murat
dc.date.accessioned2020-06-25T17:51:35Z
dc.date.available2020-06-25T17:51:35Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionAydos, Tolga Resat/0000-0002-1832-9336; Soyer, Tutku/0000-0003-1505-6042
dc.description.abstractAim To evaluate the effect of phototherapy on gastrointestinal smooth muscle activity and oxidative stress. Methods Wistar albino rats (n = 18, in the first 7 days of life) weighing 7 +/- 2 g with both sexes were included in the study. The animals were randomized into three groups. In control group (CG), median laparotomy was performed to obtain 1 cm of jejunum, terminal ileum and colonic segments. In the phototherapy group (PTG), led phototherapy with a wave density of 40 mu w/cm(2)/nm were used (Bilitron 3006, Fanem, Brasil). The efficacy surface of phototherapy was 30-40 cm and the exposure distance was 30 cm. The duration of phototherapy was 24 h. Sham group (SG) received white light with the same wave density and exposure distance. The oxidative stress markers and contraction responses were investigated from intestinal segments obtained from experiments. Results The jejunum segments showed significantly lowered contraction response to carbachol in SG when compared to CG and PTG (p < 0.05). Decreased contractile response to KCl was detected in both SG and PTG in terminal ileum segments. MDA levels showed no difference between groups (p > 0.05). Total sulfhydryl (T-SH) levels were found significantly increased in PTG when compared to CG and SG (p < 0.05). When NO levels were evaluated, NO levels were found decreased in PTG and SG with respect to CG (p < 0.05). Conclusion PT may cause various alterations in oxidant/antioxidant system in intestinal segments. Unlike to clinical findings, decreased contractile responses were detected in rat gastrointestinal smooth muscles after PT.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00383-011-2934-0
dc.identifier.endpage1202en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue11en_US
dc.identifier.pmid21630101
dc.identifier.scopus2-s2.0-80054887555
dc.identifier.scopusqualityQ2
dc.identifier.startpage1197en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-011-2934-0
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4921
dc.identifier.volume27en_US
dc.identifier.wosWOS:000297351900009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhototherapyen_US
dc.subjectNewbornen_US
dc.subjectGastrointestinalen_US
dc.subjectSmooth muscleen_US
dc.subjectPhoto-oxidationen_US
dc.titleEffect of phototherapy on gastrointestinal smooth muscle activity and oxidative stressen_US
dc.typeArticle

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