Combination of adenosine with prilocaine and lignocaine for brachial plexus block does not prolong postoperative analgesia

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dc.contributor.authorApan, A.
dc.contributor.authorBasar, H.
dc.contributor.authorÖzcan, S.
dc.contributor.authorBüyükkocak, Ü.
dc.date.accessioned2020-06-25T17:35:13Z
dc.date.available2020-06-25T17:35:13Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description1st World Congress on Regional Anaesthesia and Pain Therapy -- 2002 -- Barcelona, SPAIN
dc.description.abstractAdenosine analogues have been used by subarachnoid injection for the treatment of inflammatory and neuropathic pain. There is no data on the use of adenosine in peripheral nerve blocks. The aim of the present study was to determine the analgesic efficacy of adenosine in combination with a local anaesthetic solution for brachial plexus (BP) block With local ethics committee approval, 50 consenting adult patients undergoing upper limb surgery were enrolled in this double-blind, prospective, randomized study. Patients with a history of bronchospastic disease were excluded. Patients were instructed not to take theophylline-containing drugs and beverages for at least one day before surgery or on the first postoperative day. A supraclavicular BP block was performed by injecting a mixture totalling 35 ml made up of prilocaine 1% 10 ml and lignocaine 2% 20 ml with adrenaline 1:200 000, and adenosine 10 mg in 5 ml saline (Group 1) or 5 ml saline (Group 2) as a placebo control group. Postoperative analgesia was assessed by time to first rescue analgesia, analgesic consumption in the first 24 hours, and VAS at rest at 4, 8, 12, 16, 20 and 24 hours. Side effects were also noted. Vital signs were stable in both groups throughout the operation. There were no significant differences between the groups in onset of motor and sensory block. Time to first pain sensation from block was not significantly longer in the adenosine group (379 +/- 336 min) compared with controls (304 +/- 249 min, mean +/- SD, P=0.14). Time to first analgesic requirements and analgesic consumption in the first 24 hours were also similar in both study groups. In the present study, the addition of adenosine to local anaesthetic in brachial plexus block did not significantly extend the duration of analgesia.en_US
dc.identifier.citationApan A, Basar H, Ozcan S, Buyukkocak U.(2003). Combination of Adenosine with Prilocaine and Lignocaine for Brachial Plexus Block Does not Prolong Postoperative Analgesia. Anaesthesia and Intensive Care,31(6):648-652. doi:10.1177/0310057X0303100606en_US
dc.identifier.doi10.1177/0310057X0303100606
dc.identifier.endpage652en_US
dc.identifier.issn0310-057X
dc.identifier.issn1448-0271
dc.identifier.issue6en_US
dc.identifier.pmid14719426
dc.identifier.scopus2-s2.0-0346896366
dc.identifier.scopusqualityQ2
dc.identifier.startpage648en_US
dc.identifier.urihttps://doi.org/10.1177/0310057X0303100606
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3061
dc.identifier.volume31en_US
dc.identifier.wosWOS:000187734800006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAustralian Soc Anaesthetistsen_US
dc.relation.ispartofAnaesthesia And Intensive Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectregional anaesthesia : brachial plexus blocken_US
dc.subjectpostoperative analgesia : adenosineen_US
dc.titleCombination of adenosine with prilocaine and lignocaine for brachial plexus block does not prolong postoperative analgesiaen_US
dc.typeArticle

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