Effects of a novel biodegredable implant system on a rat tibia fracture model

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dc.contributor.authorYalçınozan, Mehmet
dc.contributor.authorTürker, Mehmet
dc.contributor.authorÇırpar, Meriç
dc.date.accessioned2021-01-14T18:21:59Z
dc.date.available2021-01-14T18:21:59Z
dc.date.issued2020
dc.description.abstractObjective: This study aimed to determine the effects of a novel biodegradable implant releasing platelet-derived growth factor (PDGF) at the fracture site on fracture healing in a rat tibia fracture model. Methods: In this study, 35 male Sprague-Dawley rats weighing between 300 and 350g were used. The rats were divided into four groups: Group A (control group without any treatment, n=10), Group B (spacer without PDGF Group, n=10), Group C (spacer with PDGF group, n=10), and Group D (healthy rat Group, n=5). Standardized fractures were created in the right tibias of rats, and then biodegradable implants made of poly-?-hydroxybutyrate-co-3-hydroxy valerate were implanted at the fracture sites in Groups B and C. In Group C, implants were loaded with 600 ng of PDGF. Animals were sacrificed 30 days after the operation, and fracture healing in each group was assessed radiologically based on the Goldberg score. Furthermore, the anteroposterior (AP) and mediolateral (ML) callus diameters were measured macroscopically, and fracture sites were mechanically tested. Results: In the radiological assessment, Group C showed higher fracture healing rate than Groups A and B (p=0.001), whereas no significant difference was found between group C and Group D (p>0.05). In the macroscopic assessment, while Group C exhibited the thickest AP callus diameter (p=0.02), no significant differences in ML callus diameters existed among the groups (p>0.05). Mechanical testing revealed that Group C had higher torsional strength (p=0.001) and stiffness than Groups A and B (p=0.001) while there was no significant difference between Groups C and D (p>0.05).en_US
dc.identifier.citationYalçınozan, M., Türker, M., & Çırpar, M. (2020). Effects of a novel biodegredable implant system on a rat tibia fracture model. Acta orthopaedica et traumatologica turcica, 54(4), 453–460.en_US
dc.identifier.doi10.5152/j.aott.2020.18331
dc.identifier.endpage460en_US
dc.identifier.issn1017-995X
dc.identifier.issue4en_US
dc.identifier.pmid32812878
dc.identifier.scopus2-s2.0-85089768742
dc.identifier.scopusqualityQ2
dc.identifier.startpage453en_US
dc.identifier.trdizinid380150
dc.identifier.urihttps://doi.org/10.5152/j.aott.2020.18331
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpnd01UVXdNQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12587/13972
dc.identifier.volume54en_US
dc.identifier.wosWOS:000563028600015
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofActa Orthopaedica et Traumatologica Turcica
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of a novel biodegredable implant system on a rat tibia fracture modelen_US
dc.typeArticle

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