Evaluation of once daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in spayed bitches

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dc.contributor.authorKanca, Halit
dc.contributor.authorKarakas, Kubra
dc.contributor.authorYagci, Ilknur Pir
dc.contributor.authorBasaran, Timucin
dc.date.accessioned2020-06-25T18:06:48Z
dc.date.available2020-06-25T18:06:48Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study was to evaluate the efficacy and long term safety of once daily administration of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in spayed bitches in comparison to three times daily administrations. For this purpose, 22 spayed bitches suffering from USMI received either PPA at the dose rate of 1.5 mg/kg, body weight (BW) once daily (group I, n=11) or 1.5 mg/kg three times daily (group II, n=11) by oral administration. Clinical efficacy was determined by using a scoring system based on analysing the frequency and the amount of unconscious urination on d 7, 14 and 28. There was no significant difference (p>0.05) between the clinical response observed on d 7, 14 and 28 of treatment in group I and II. Eight dogs (72.7%) in each group were continent on d 28. The side effects observed were mild and transient. Phenylpropanolamine therapy was continued in 13 dogs that became continent after 28 d and the dogs were followed up for 12 months. None of the dogs showed symptoms of urinary incontinence except for 2 bitches that became refractory to PPA treatment in group II. Phenylpropanolamine was combined with estriol for 14 d (1 mg/dog PO) in dogs in which PPA therapy was inefficient or unsatisfactory on d 28 and in dogs that became refractory to PPA treatment. A total of 8 dogs were treated with estriol PPA combination. Five (62.5%) bitches were continent on 14th d of estriol PPA combination treatment. In one bitch (12.5%) urinary incontinence improved. In conclusion, once daily administration of PPA at a dose of 1.5 mg/kg, BW is effective in treatment of USMI in spayed bitches and it offers a cheap and convenient treatment option. In addition, recurrence of incontinence can be observed during long term administration of PPA and combination of PPA with estriol is effective in dogs in which PPA therapy alone is unsatisfactory and in dogs that become refractory to PPA treatment.en_US
dc.identifier.citationKanca H., Alkan K. K., Yağcı İ. P., Başaran T. (2012). Evaluation of once daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in spayed bitches. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 59(3), 203 - 210.en_US
dc.identifier.doi10.1501/Vetfak_0000002526
dc.identifier.endpage210en_US
dc.identifier.issn1300-0861
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84860111722
dc.identifier.scopusqualityQ3
dc.identifier.startpage203en_US
dc.identifier.trdizinid132163
dc.identifier.urihttps://doi.org/10.1501/Vetfak_0000002526
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5357
dc.identifier.volume59en_US
dc.identifier.wosWOS:000306099600008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEstriolen_US
dc.subjectphenylpropanolamineen_US
dc.subjectspayed bitchen_US
dc.subjecturethral sphincter mechanism incompetenceen_US
dc.titleEvaluation of once daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in spayed bitchesen_US
dc.typeArticle

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