Focusing-free impedimetric differentiation of red blood cells and leukemia cells: A system optimization
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE SA
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A focusing-free microfluidic impedimetric cell detection system is developed. The effect of the channel dimensions, solution conductivity, excitation voltage, and particle size on impedimetric signal outputs were optimized to increase the sensitivity of the system. Conventional microfabrication techniques were adapted to obtain low height, resealable microchannels. The geometry optimization was performed by a combination of analytical, numerical and experimental approaches. The results demonstrate that reliable impedimetric particle differentiation can be achieved without any labeling or particle focusing. The system parameters were studied and rule-of-thumb design criteria were provided. Finally, using the developed system, red blood cells and leukemia cells were experimentally detected and differentiated. Thanks to its simplicity, the focusing-free cell differentiation system may find applications in several cellular diagnostic uses.
Açıklama
GULER, MUSTAFA TAHSIN/0000-0002-0478-3183
Anahtar Kelimeler
Impedance spectroscopy, Red blood cell, White blood cell, Leukemia, Microfluidic flow cytometry
Kaynak
SENSORS AND ACTUATORS B-CHEMICAL
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
307
Sayı
Künye
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